I'm glad you have read about lectins and are considering how they effect you. This whole topic is what lead me to primal as nightshades (tomatoes, potatoes, peppers and eggplant) have caused me so many immune problems (RA,OA, possible fibromyalgia) and when I cut them out, I essentially got my life back! Potatoes in particular caused me so much pain. The one caution I would have for you about cutting out only one at a time is that if it is a group that causes you problems, then you may never discover this. When I cut out nightshades, the difference was tremendous in just one week, so you may see differences quickly. Also, it can take the body a while to heal or clear a toxin from it, so give your changes time (this coming from a very impatient person - so good luck)!