Isabell, I'm at a similar point as you are. I wondered if I have leaky gut, so I did a VAP, HS CRP, and RT3/FT3 and learned how to attempt to hack the results. I saw that my HDL was at 68, and...
Dr. K says "...down around 40 is a marker for leaky gut". And more, "A high HDL is a sign of good liver function. Remember that HDL particles actually bind inflammatory endotoxin particles to increase our immunity from oxidation from many sources. This is why a high HDL level confers general health and well being across the board." Moreover, VLDL and chylomicrons also protect us from inflammatory damage as well. This biologic process is at the seat of why we see higher cholesterol levels in the face of cellular stress or infection."
Hmm. I still wondered, so I went off all dairy, wheat, nightshades, grains, eggs, all in a test to see how I did. I am also coming at this with an autoimmune angle and these are all irritants. I had started the Leptin Reset two weeks earlier and really chowed down on the coconut oil and bone broths, both heal leaky gut. I figured I'd give it the best shot I can. Experimentation and observation.
Other test to compare are HS CRP and Thyroid screening.
Kruse again, "The increased secretion of TSH from the pituitary has a major effect on out liver too. It is pro-inflammatory because it causes the liver to make HS-CRP (Highly Sensitive . HS-CRP is what we used to measure baseline inflammation in patients. It is called an acute phase reactant protein. High CRP levels are known to walk hand and hand with the development of atherosclerosis. The increased CRP produces multitudes or pro inflammatory chemicals body wide, because they activate immune cells like Mast cells. Mast cells and other immune cells, are the factories of pro inflammatory chemicals and they stimulate more inflammation in the plaques of atheromas in blood vessels to rupture and cause disease.
More Kruse: "If you read about nightshades, they cause issues similar to a leaky gut. So if you re read my VAP= Leaky gut post you will see that I use the VAP as a proxy to see if the gut is leaky. Most people doing a reset all have really bad HDL levels. This means the liver is not as good a filter as it could be. IE the gut is leaky to more inflammation than it need be. This is also why the HS CRP is higher. It tells us that the plasma is more oxidative to our systems. And this fosters leptin resistance. Therefore, during the reset we want to do everything possible to eliminate inflammation and that is why you should avoid the nightshades. And if you happen to get a lipid panel on your reset……and as a female your HDL is above 60, or as a male above 70, then I say you can eat nightshades on the reset. In my six years of doing this I have not seen a LR person who fit that bill as yet."
K: "High TSH levels are not good signs. This is why hypothyroidism is correlated with heart disease and many autoimmune conditions. Hashimoto’s thyroiditis is an epidemic in America and in my view is a sign of a constant assault of the intestinal brush border of our gut that eventually overwhelms it and then floods the portal circulation with inflammation. This results in a liver response that, over time, goes from favorable (particle A LDL size with high HDL) to a very unfavorable particle B size dominated by sdLDL and low HDL and a high HS CRP. This then sets the stage for disease propagation in many sites of the body."
My autoimmune issues (possible Lyme infection) has it's own set of pathways which I'm struggling to learn. But I feel like my Leaky Gut is being addressed if need be. It's good basic human nutrition. And those broths are so good!!!!