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Thread: Leptin Reset Experiment starts today - Jack Kruse style page 1363

  1. #13621
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    Isabell, I'm at a similar point as you are. I wondered if I have leaky gut, so I did a VAP, HS CRP, and RT3/FT3 and learned how to attempt to hack the results. I saw that my HDL was at 68, and...

    Dr. K says "...down around 40 is a marker for leaky gut". And more, "A high HDL is a sign of good liver function. Remember that HDL particles actually bind inflammatory endotoxin particles to increase our immunity from oxidation from many sources. This is why a high HDL level confers general health and well being across the board." Moreover, VLDL and chylomicrons also protect us from inflammatory damage as well. This biologic process is at the seat of why we see higher cholesterol levels in the face of cellular stress or infection."

    Hmm. I still wondered, so I went off all dairy, wheat, nightshades, grains, eggs, all in a test to see how I did. I am also coming at this with an autoimmune angle and these are all irritants. I had started the Leptin Reset two weeks earlier and really chowed down on the coconut oil and bone broths, both heal leaky gut. I figured I'd give it the best shot I can. Experimentation and observation.

    Other test to compare are HS CRP and Thyroid screening.

    Kruse again, "The increased secretion of TSH from the pituitary has a major effect on out liver too. It is pro-inflammatory because it causes the liver to make HS-CRP (Highly Sensitive . HS-CRP is what we used to measure baseline inflammation in patients. It is called an acute phase reactant protein. High CRP levels are known to walk hand and hand with the development of atherosclerosis. The increased CRP produces multitudes or pro inflammatory chemicals body wide, because they activate immune cells like Mast cells. Mast cells and other immune cells, are the factories of pro inflammatory chemicals and they stimulate more inflammation in the plaques of atheromas in blood vessels to rupture and cause disease.

    More Kruse: "If you read about nightshades, they cause issues similar to a leaky gut. So if you re read my VAP= Leaky gut post you will see that I use the VAP as a proxy to see if the gut is leaky. Most people doing a reset all have really bad HDL levels. This means the liver is not as good a filter as it could be. IE the gut is leaky to more inflammation than it need be. This is also why the HS CRP is higher. It tells us that the plasma is more oxidative to our systems. And this fosters leptin resistance. Therefore, during the reset we want to do everything possible to eliminate inflammation and that is why you should avoid the nightshades. And if you happen to get a lipid panel on your reset……and as a female your HDL is above 60, or as a male above 70, then I say you can eat nightshades on the reset. In my six years of doing this I have not seen a LR person who fit that bill as yet."


    K: "High TSH levels are not good signs. This is why hypothyroidism is correlated with heart disease and many autoimmune conditions. Hashimoto’s thyroiditis is an epidemic in America and in my view is a sign of a constant assault of the intestinal brush border of our gut that eventually overwhelms it and then floods the portal circulation with inflammation. This results in a liver response that, over time, goes from favorable (particle A LDL size with high HDL) to a very unfavorable particle B size dominated by sdLDL and low HDL and a high HS CRP. This then sets the stage for disease propagation in many sites of the body."


    My autoimmune issues (possible Lyme infection) has it's own set of pathways which I'm struggling to learn. But I feel like my Leaky Gut is being addressed if need be. It's good basic human nutrition. And those broths are so good!!!!
    Martin

  2. #13622
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    Quote Originally Posted by Isabell View Post
    I was diagnosed with leaky gut, but the doc who did never explained it or discussed how to cure it. She just sold me a bottle of probiotics, told me to make Soy protein shakes every morning for breakfast and that was that. Until I found this thread and the Leptin RX I had no idea that what she had done with her "treatment" complicated my hypothyroid condition (which she missed). And I had no idea that the leaky gut was the entry point for solving biohacks. Ah well.

    I have NO IDEA what she tested to give me the diagnosis of leaky gut, and I am still looking for a way to figure out if it is healing, healed, etc. I think if I understand my reading of this thread correctly (and Dr. Kruse's site) that the VAP can be used. I think if you have mostly large "A type" LDLs versus "B type" LDLs then you don't have leaky gut and if it is the other way around then you DO have a leaky gut. BUT, my previous doctor never did a VAP or NMR on me, so I have no clue how she arrived at the diagnosis.

    Please someone correct me if that is not how you can diagnose leaky gut...

    Also, how come you want to avoid EVOO? I prefer the CO, pastured butter, ghee too. Just curious.
    Isabell, I'm at a similar point as you are. I wondered if I have leaky gut, so I did a VAP, HS CRP, and RT3/FT3 and learned how to attempt to hack the results. I saw that my HDL was at 68, and...

    Dr. K says "...down around 40 is a marker for leaky gut". And more, "A high HDL is a sign of good liver function. Remember that HDL particles actually bind inflammatory endotoxin particles to increase our immunity from oxidation from many sources. This is why a high HDL level confers general health and well being across the board." Moreover, VLDL and chylomicrons also protect us from inflammatory damage as well. This biologic process is at the seat of why we see higher cholesterol levels in the face of cellular stress or infection."

    Hmm. I still wondered, so I went off all dairy, wheat, nightshades, grains, eggs, all in a test to see how I did. I am also coming at this with an autoimmune angle and these are all irritants. I had started the Leptin Reset two weeks earlier and really chowed down on the coconut oil and bone broths, both heal leaky gut. I figured I'd give it the best shot I can. Experimentation and observation.

    Other test to compare are HS CRP and Thyroid screening.

    Kruse again, "The increased secretion of TSH from the pituitary has a major effect on out liver too. It is pro-inflammatory because it causes the liver to make HS-CRP (Highly Sensitive . HS-CRP is what we used to measure baseline inflammation in patients. It is called an acute phase reactant protein. High CRP levels are known to walk hand and hand with the development of atherosclerosis. The increased CRP produces multitudes or pro inflammatory chemicals body wide, because they activate immune cells like Mast cells. Mast cells and other immune cells, are the factories of pro inflammatory chemicals and they stimulate more inflammation in the plaques of atheromas in blood vessels to rupture and cause disease.

    More Kruse: "If you read about nightshades, they cause issues similar to a leaky gut. So if you re read my VAP= Leaky gut post you will see that I use the VAP as a proxy to see if the gut is leaky. Most people doing a reset all have really bad HDL levels. This means the liver is not as good a filter as it could be. IE the gut is leaky to more inflammation than it need be. This is also why the HS CRP is higher. It tells us that the plasma is more oxidative to our systems. And this fosters leptin resistance. Therefore, during the reset we want to do everything possible to eliminate inflammation and that is why you should avoid the nightshades. And if you happen to get a lipid panel on your reset……and as a female your HDL is above 60, or as a male above 70, then I say you can eat nightshades on the reset. In my six years of doing this I have not seen a LR person who fit that bill as yet."


    K: "High TSH levels are not good signs. This is why hypothyroidism is correlated with heart disease and many autoimmune conditions. Hashimoto’s thyroiditis is an epidemic in America and in my view is a sign of a constant assault of the intestinal brush border of our gut that eventually overwhelms it and then floods the portal circulation with inflammation. This results in a liver response that, over time, goes from favorable (particle A LDL size with high HDL) to a very unfavorable particle B size dominated by sdLDL and low HDL and a high HS CRP. This then sets the stage for disease propagation in many sites of the body."


    My autoimmune issues (possible Lyme infection) has it's own set of pathways which I'm struggling to learn. But I feel like my Leaky Gut is being addressed if need be. It's good basic human nutrition. And those broths are so good!!!!

    Martin

  3. #13623
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    Quote Originally Posted by Isabell View Post
    Totally understand what you are saying. I was only able to lose weight on low carb and the weight only stayed off if I stayed on the low carb (without knowing that was what I was doing). I was eating an anti-inflammatory diet when I was able to lose the weight. HOWEVER, the extreme fatigue stayed though the pain lessened. I just pushed through the fatigue since it was marginally better after the weight was gone. This time I haven't dropped enough weight to know if the fatigue or pain will lessen. I know this is expensive, I have probably spent over $36,000 dollars out of my own pocket in the last 23 years trying to find a cure. I've had 4 "exacerbations" of this illness, each time more severe and longer. This time it's been 4 years. I've been through every kind of specialist including a University of Michigan "specialist" who said diet had nothing to do with health! (Talk about CLUELESS). I never went back there.

    I get the biotoxin pathway and how it may be causing my issues (at least enough to start for now). I guess what I'm trying to figure out is a logical step-by-step process to narrow down what it may be without doing testing that may not be necessary to figure out if the treatment is worth a try.

    So if I have active Lyme, I would need to identify that or a staph infection first since those would need to be treated with antibiotics first. So, would MSH, CD57 and the coagulase negative Staph test be enough to identify the basis for a biotoxin treatment?

    If CD57 and coagulase negative Staph test are fine but MSH is low then I can go ahead with the treatment meds. If there is a positive for either the CD57 or the coagulase negative Staph test then I need those treated with antibiotics first before going on the biotoxins treatment meds? YES???

    Does that seem like a reasonable approach to suggest to my doctor?

    Thank you!
    Have you done the Visual Acuity Test from Dr. Shoemaker? Welcome to ChronicNeurotoxins, Inc. Home Page

    I just did and it showed positive for neurotoxins. It's just another step in the way forward. I'm looking at doing MSH, C4a, and MMP-9 soon.

    My CD57 came back 70 in a lab range of 60 - 360. From what I've read, you want it on the high side.

    My Lyme IgG/IgM Ab came back 1.01 in a range of 0.00 to .90. VERY high!

    Also, IgM23 Ab was "Present". and 5 of the following Borrelia-specific bands: 18, 23, 28, 30, 39, 41, 45, 58, 66, and 93.

    My reluctance to go down the abx path is almost gone. Dr. K answered what I have all along felt was the best course of action, except so many folks had not been helped by months of abx's. That has had me spooked, especially after learning so much about dysbiosis (leaky gut). But there comes a time when one must move on it and go with the nuclear option.

    Martin

  4. #13624
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    Quote Originally Posted by goldilocks View Post
    I received my lab results and unfortunately, the doctor forgot to order the Thyroid tests that I had asked for. But here is the rest of them.
    Am I correct in reading that the Pregnenlone and DHEA seem low. What can I do. I have started on Pregnenlone 50 mg daily.

    Thank you for your time to review and your comments.

    Lab Test Result Range
    12/9/2011
    VAP
    LDL 137.7 70-130
    Total LDL-C Direct 134 <130
    Total HDL-C Direct 147 >40
    Total VLDL-C Direct 13 <30
    Total Cholesterol 294 <200
    Triglycerides 52 <150
    Total APOB100 - Calc 85 <109
    Total Non-HDL-C (LDL+VLDL) 147 <160
    LP9a) Cholesterol 17 <10
    IDL-C 6 <20
    Real -LDL-C 111 <100
    Total LDL-C 134 <130
    Remnant Lip (IDL+VLDL3) 14 <30
    HDL-2 (large Buoyant) 65 >15
    HDL-3 82 >25
    VLDL-3 8 <10

    HS CRP 3 0-10

    Magnesium 1.5-2.5
    B12 1680 230-1050
    Cortisol (blood) 12.9 4.0-22.0
    SHBG 320 17-124

    Pregnenolone 42 7-188
    DHEA Sulfate 44 150-170

    Vitamin D, 25-OH 80 30-100
    Vitamin D 25-OH, D2 <4

    Ferritin 78 10-232
    Iron 67 50-170

    CBC
    Glucose, Fasting 65 65-99
    BUN 13 7-25.0
    Creatinine 6 0.76-1.46
    Calcium 8.9 8.6-10.2
    Total Protein 7.1 6.2-8.3
    Albumin 4.5 3.6-5.1
    AST (SGOT) 16 010-35
    ALT (SGPT) 23 9.0-60
    Potassium 4.2 3.5-5.3

    Globulin 2.6 1.5-4.5
    Albumin/Globulin Ratio 1.6 1.0-2.1
    assume goldilocks=womam
    assume, blood drawn in the morning

    Pregnenolone 42 7-188
    DHEA Sulfate 44 150-170
    Cortisol (blood) 12.9 4.0-22.0
    --------------------------------------------
    Glucose, Fasting 65 65-99
    SHBG 320 17-124
    doctor forgot to order the Thyroid tests
    insulin fasing=????
    --------------------------------------------
    Albumin 4.5 3.6-5.1
    AST (SGOT) 16 010-35
    ALT (SGPT) 23 9.0-60
    --------------------------------------------
    Total HDL-C Direct 147 >40
    You have very high SHBG
    often insulin resistance or low TT3
    and million other unknowns

    Total HDL-C Direct 147
    cannot be good, indicate gross unbalance
    per general lattest dr K's theory, high HDL=good, no leaky gut, specially good liver
    but we also have you with very high SHBG, we need to slow down your liver so it makes less of SHBG

    Known parts of Steroid Hormone Panel
    pregnenolone, DHEAs, cortisol,
    all are low

    highly likely the rest of Steroid Hormones are also low.
    testosterone and estrogens bind to SHBG
    regardles of their total values, their free fraction (that actually works) will be very low.

    --------------------

    In regard to steroid hormones I think that you should join your Mom, very similar situation.


    http://www.marksdailyapple.com/forum/thread42106.html



    ////
    Last edited by JanSz; 01-13-2012 at 03:24 PM.

  5. #13625
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    I just got my latest labs done, no thyroid for some reason the doc put it off three months. Go figure.

    Here is where I am after 5 months grain sugar linoleic acid free (some sporadic white potatoes and tomatoes, some raw milk cheese). This will have to be my baseline as my older labs will not be given to me despite me getting a bit testy with them.

    HDL 89
    Trig. 75
    hsCRP 2

    Can I assume LS ness? I am actually doing reset with spouse to keep meals same.
    I am undergoing orthodontia. My teeth hurt a bit so assuming there is a bit of inflammation and I just had arthroscopic rotator cuff repairs with subacromial decompression, still a bit of posterior capsule tightness. Can those things increase crp?
    Last edited by Snauzoo; 01-13-2012 at 03:25 PM.

  6. #13626
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    Quote Originally Posted by JanSz View Post
    assume goldilocks=womam
    assume, blood drawn in the morning



    You have very high SHBG
    often insulin resistance or low TT3
    and million other unknowns

    Total HDL-C Direct 147
    cannot be good, indicate gross unbalance
    per general lattest dr K's theory, high HDL=good, no leaky gut, specially good liver
    but we also have you with very high SHBG, we need to slow down your liver so it makes less of SHBG

    Known parts of Steroid Hormone Panel
    pregnenolone, DHEAs, cortisol,
    all are low

    highly likely the rest of Steroid Hormones are also low.
    testosterone and estrogens bind to SHBG
    regardles of their total values, their free fraction (that actually works) will be very low.

    --------------------

    In regard to steroid hormones I think that you should join your Mom, very similar situation.


    http://www.marksdailyapple.com/forum/thread42106.html



    ////
    Thank you Jan for your response.

    I have been taking 50mg Pregnenlone daily.
    I have but have not started taking: DHEA 25 mg and 7-Keto 50 mg.
    would one cap per day of each be enough, or do I need more?
    Based on the above test what other tests should I do to check for the imbalances?

    Fara

  7. #13627
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    Quote Originally Posted by Snauzoo View Post
    Question for Dr. Kruse.

    I am looking for the Nov. 2011 issue of Journal of Orthomolecular Medicine where there is an article on use of inositol on non ulcer dyspepsia secondary to decreased acid production. Our med library copy is missing. I did a huge inositol challenge for my GERD following 2 npmonths PPI usage. It works. I took 3 g/d.

    Do you have perchance? I forgot the researchers name (s).

    Thnx
    no I dont

  8. #13628
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    Quote Originally Posted by JanSz View Post
    From what I can gather, there is no complete MSH replacement available.

    In dr Hergoghe's book I see, α, β, y fractions
    and synthetics
    melanotan I
    melanocortin I
    melanotan II
    melanocortin II
    bremelanotide

    How to determine the applicable one?

    Further in the book it looks like he concentrates on (probably easier available) Melanotan II and Bremelanotide.


    ...
    correct.......there is a better way but I am not talking about it just yet.

  9. #13629
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    Quote Originally Posted by Oldschool View Post
    Have you done the Visual Acuity Test from Dr. Shoemaker? Welcome to ChronicNeurotoxins, Inc. Home Page

    I just did and it showed positive for neurotoxins. It's just another step in the way forward. I'm looking at doing MSH, C4a, and MMP-9 soon.

    My CD57 came back 70 in a lab range of 60 - 360. From what I've read, you want it on the high side.

    My Lyme IgG/IgM Ab came back 1.01 in a range of 0.00 to .90. VERY high!

    Also, IgM23 Ab was "Present". and 5 of the following Borrelia-specific bands: 18, 23, 28, 30, 39, 41, 45, 58, 66, and 93.

    My reluctance to go down the abx path is almost gone. Dr. K answered what I have all along felt was the best course of action, except so many folks had not been helped by months of abx's. That has had me spooked, especially after learning so much about dysbiosis (leaky gut). But there comes a time when one must move on it and go with the nuclear option.

    Martin
    awesome news.......

  10. #13630
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    Quote Originally Posted by goldilocks View Post
    Thank you Jan for your response.

    I have been taking 50mg Pregnenlone daily.
    I have but have not started taking: DHEA 25 mg and 7-Keto 50 mg.
    would one cap per day of each be enough, or do I need more?
    Based on the above test what other tests should I do to check for the imbalances?

    Fara
    Goals use only LabCorp to do the testing

    This is for day 3-4 of menstrual cycle (they are the lowest levels during cycle)

    Pregnenolone--230 ng/dL
    Progesterone~1.4 ng/mL
    DHEAs---(275-400) μg/dL
    Estradiol,sensitive (15-30)pg/mL

    You will have to guess doses and then do blood test, see where you are, then increase or decrease doses.

    Depending on what kind pregnenolone you use, MLM seems works at smaller dose, plain requires higher dose.
    Do not be surprised if you end up on something like

    100mg 7ketoDhea
    200mg DHEA
    1000mg(thousand) Pregnenolone

    at certain point, pregnenolone tests results are not important, go only by progesterone

    When you think that you are good, next test shows that you have too much.
    There is re-bound effect, be aware of that.

    At certain point you may want to (still using only pregnenolone pills), watch progesterone, cortisol and possibly Aldosterone.

    You have a flexibility with pregnenolone & progesterone levels, you worry most about cortisol.

    ==================================
    I am not sure of what to do with this:

    In the morning, when you wakeup, you have certain cortisol level.
    If you exposure your face and eyes to sun for 30 minutes, you may increase your cortisol for up to 50% (good, very good).


    Should we look on the sun in the morning, when going for blood test that includes cortisol testing?
    I know we should be calm and collected, so as not to loose cortisol.
    If someone, on our way to lab, cuts us off in the traffic that may affect cortisol test.
    Quickie in the morning is good for mood and oxytocin, bad for cortisol.


    ......
    Last edited by JanSz; 01-13-2012 at 04:10 PM.

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