The common element of both studies is not "muscle fatigue", but "muscle failure" - there's a difference. The latter is more clearly defined and essentially means that you perform an exercise until it's no longer physically possible for you to perform another repetition.
It's certainly nice to know that you can get similar results with more repetitions / higher durations at least in relatively untrained persons or especially the elderly/weak, whom you would have great difficulty getting to move heavy weights. But I think that as you progress, you may need to move towards using heavier weights and fewer repetitions. Check out reference study #52:
Twitch contractile adaptations are not dependent o... [Eur J Appl Physiol Occup Physiol. 1990] - PubMed result
" were determined in six healthy but very sedentary subjects before and after 16 weeks of isometric training"
There are a lot of studies out there which are based on test subjects which are basically untrained. For those people, most types of training will lead to improvement. A study is much more significant if it is based on subjects who either have som basic training, or which are sufficiently randomized in terms of progress and body type - but of course the latter would be much more expensive, since it would have to involve much more subjects.



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