I was getting worse and worse RLS (never diagnosed....refused to go to the doctor about a condition I only knew about from drug advertisements!) It's actually one of the things that led me to primal.
Mine seems to be primarily an iron issue. But I also think it was made much worse by blood sugar variability. Fixing my iron levels and going primal has almost 100% eliminated it. The very minor sensations I occasionally get these days, I would probably never have noticed pre-RLS.
Zone diet on and off for several years....worked, but too much focus on exact meal composition
Primal since July 2010...skinniest I've ever been and the least stressed about food