I just read the AcOH Japanese study , and it really looked interesting.
A few takeaways:
- The effects are due to AMPK phosphorylation, not loss of water.
- Effects are dose dependent. Higher doses produce better results.
- Effects initially manifested after 4 weeks.
AMPK is your best friend, get to know it, you'll get along swimmingly!
AMPK induces a cascade of events within cells in response to the ever changing energy charge of the cell. The role of AMPK in regulating cellular energy charge places this enzyme at a central control point in maintaining energy homeostasis.
AMPK inhibits pancreatic beta cell insulin secretion, as well as inhibiting fatty acid synthesis in the liver and adipose tissue.
AMPK promotes fatty acid oxidation and glucose uptake in both skeletal and heart muscle, as well as promoting increased glycolysis in cardiac muscle.
The experimental protocol called for the AcOH to be drunk after the meals, but I suspect that this was due to a desire to not have the beverage potentially affect the amount of food consumed by the subjects. Because of the mechanism of action of AMPK, it might make more sense to ingest AcOH before meals. Nevertheless, if you want to remain faithful to the experiment, drink a 250 ml. apple vinegar cocktail after breakfast, and another after dinner. The high dose effectively doubled the amount of vinegar ingested from 15 ml. to 30 ml. per day which translated into 750 mg. and 1500 mg. of acetic acid. Keep this up for 4 weeks, and see where that gets you!
I'm game. I like vinegar and this sounds like a fairly painless way to get some results.