I only lost 80 pounds and once I hit that I basically ran to the gym. I don't think their is anything that will drasticly help in the short term but I have gained alot of muscle and that has helped fill in the loose skin. Also many people will tell you lotion such as cocoa and shea butter with Q10 won't help but it has visibly helped my stretch marks and skins ability to "bounce" back. It has taken a few months applying two-three times a day along with working out as hard as possible but it is helping. Good luck man.