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  1. #1
    ann112358's Avatar
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    Post The Grapefruit Diet -- not crazy!

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    Just read this about my favorite 60's fad diet. Molecular medicine is the bomb! There's a link to the full journal article at the end.

    Grapefruit's bitter taste holds a sweet promise for diabetes therapy

    Naringenin, an antioxidant derived from the bitter flavor of grapefruits and other citrus fruits, may cause the liver to break down fat while increasing insulin sensitivity, a process that naturally occurs during long periods of fasting.

    A team of researchers from the Hebrew University of Jerusalem and Massachusetts General Hospital (MGH) report that naringenin activates a family of small proteins, called nuclear receptors, causing the liver to break down fatty acids. In fact, the compound seems to mimic the actions of other drugs, such as the lipid-lowering Fenofibrate and the anti-diabetic Rosiglitazone, offering the advantages of both. If the results of this study extend to human patients, this dietary supplement could become a staple in the treatment of hyperlipidemia, type-2 diabetes, and perhaps metabolic syndrome. The report appears in this week issue of the online journal PLoS ONE.

    "It is a fascinating find," says Yaakov Nahmias, PhD, of the Hebrew University of Jerusalem the paper's senior author. "We show the mechanism by which naringenin increases two important pharmaceutical targets, PPARα and PPARγ, while blocking a third, LXRα. The results are similar to those induced by long periods of fasting".

    The liver is the main organ responsible for the regulation of carbohydrate and lipid levels in the blood. Following a meal, the blood is flushed with sugars, which activate LXRα, causing the liver to create fatty acids for long-term storage. During fasting, the process is reversed; fatty acids are released by fat cells, activate PPARα in the liver, and are broken down to ketones. A similar process, involving PPARγ, increases sensitivity to insulin.

    "It is a process which is similar to the Atkins diet, without many of the side effects," says Martin L. Yarmush, MD, PhD, director of the MGH Center for Engineering in Medicine and one of the paper's authors. (SIDE EFFECTS???? I hope they don't mean, losing weight, normalized blood lipids and increased insulin sensitivity!)

    "The liver behaves as if fasting, breaking down fatty acids instead of carbohydrates." Yarmush is the Helen Andrus Benedict Professor of Surgery and Bioengineering at Harvard Medical School.

    "Dual PPARα and PPARγ agonists, like naringenin, were long sought after by the pharmaceutical industry," says Nahmias, "but their development was plagued by safety concerns. Remarkably, naringenin is a dietary supplement with a clear safety record. Evidence suggests it might actually protect the liver from damage."

    Grapefruit's bitter taste is caused the presence of the flavonoid naringin, which is broken down in the gut into naringenin. Earlier evidence has shown the compound has cholesterol lowering properties and may ameliorate some of the symptoms associated with diabetes. The researchers demonstrated that the compound activates PPARα and PPARγ by dramatically increasing the levels of a co-activator peptide of both, called PGC1α. At the same time, naringenin bound directly to LXRα, blocking its activation. These effects culminated with increased fatty acid oxidation and the inhibition of vLDL ('bad cholesterol') production.

    ###

    Additional co-authors of the PLoS ONE paper are Jonathan Goldwasser, PhD, Eric Yang, PhD, MGH; Pazit Cohen, PhD, Hebrew University; and Patrick Balaguer, PhD, INSERM Univ. Montpellier France. The work was supported by grants from the National Institutes of Health (NIH) and European Research Council (ERC).

    Citation: Goldwasser J, Cohen PY, Yang E, Balaguer P, Yarmush ML, et al. (2010) Transcriptional Regulation of Human and Rat Hepatic Lipid Metabolism by the Grapefruit Flavonoid Naringenin: Role of PPARa, PPARc and LXRa. PLoS ONE 5(8): e12399. doi:10.1371/journal.pone.0012399

    Competing Interests: The authors have declared that no competing interests exist.

    Funding: This work was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (K01DK080241), a European Research Council starting grant (TMIHCV 242699), and the Harvard Clinical Nutrition Research Center (P30-DK040561). Resources were provided by the BioMEMS Resource Center (P41 EB-002503), Shriners Burns Hospital, and the Alexander Silberman Institute of Life Sciences. The funders had no role in study design, data collection and analysis,decision to publish, or preparation of the manuscript.

    PLEASE LINK TO THE SCIENTIFIC ARTICLE IN ONLINE VERSIONS OF YOUR REPORT (URL goes live after the embargo ends): http://dx.plos.org/10.1371/journal.pone.0012399

    FOR A PRESS-ONLY PREVIEW OF THE FULL ARTICLE, VISIT THE FOLLOWING URL: http://www.plos.org/press/pone-05-08-nahmias.pdf

    Disclaimer

    This press release refers to upcoming articles in PLoS ONE. The releases have been provided by the article authors and/or journal staff. Any opinions expressed in these are the personal views of the contributors, and do not necessarily represent the views or policies of PLoS. PLoS expressly disclaims any and all warranties and liability in connection with the information found in the release and article and your use of such information.

    About PLoS ONE

    PLoS ONE is the first journal of primary research from all areas of science to employ a combination of peer review and post-publication rating and commenting, to maximize the impact of every report it publishes. PLoS ONE is published by the Public Library of Science (PLoS), the open-access publisher whose goal is to make the world's scientific and medical literature a public resource.

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    Sam Cree's Avatar
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    Interesting. I've always loved grapefruit, but have not eaten many since going "primal," figuring it had too much sugar. But it sounds fairly "primal" after all. I've got one in the refrigerator, waiting for the right moment. Funny, but grapefruits taste sweeter now than Coke used to.

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    Quote Originally Posted by Sam Cree View Post
    Interesting. I've always loved grapefruit, but have not eaten many since going "primal," figuring it had too much sugar. But it sounds fairly "primal" after all. I've got one in the refrigerator, waiting for the right moment. Funny, but grapefruits taste sweeter now than Coke used to.
    I used to have to sprinkle a TON of sugar on a grapefruit to eat it, and now I find them wonderfully sweet and delicious nekked!

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    Acteon's Avatar
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    The grapefruit is a relatively recent hybrid from the Pomelo and the Jamaican sweet orange so Grok wouldn't have eaten grapefruit.

    One of my relatives takes heart medicine and isn't allowed to take grapefruit with it. Other citrus fruit are fine though.

    Orange skins are said to be good against skin cancer:
    http://www.livestrong.com/article/12...melanoma-risk/

    I also read an article a while back that said that if you eat the pith and skin of an orange with the orange, you will not experience as much of an insulin spike as if you only ate the orange center. I looked but couldn't find the article on the Internet again.

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    Grok wouldn't recognize the vast majority of fruits and vegitables we eat, won't stop me from eating them.

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