Make sure your nails are trimmed short if they are not already. I found that helped quite a bit. I also developed a bit of a hot spot around the bottom of my big toe near the ball of my foot initially. I just made sure I took them off if I started to get a little sore, and I started putting in a bit of baking soda. After about a week of increasing my time around the house and in the yard they stretched a bit, my toes were much more comfortable all over, and no more hot spots. Now I can go about 5.5 miles on a hike after 6 weeks with no problems. I cannot go further yet....start to get some warm/wear spots in a couple areas if I go further. Being careful I have had any blisters or problems like that. I wear them 5-6 days a week for hiking, crossfit, and trail runs.