It has been suggested that one difference between us moderns and our primal ancestors is that our primal ancestors undoubtedly chewed their food a lot more thoroughly. They did not have the option of going to a grocery store, buying a quantity of food, and bolting it down without chewing it much. If they were eating edible leaves or fruit, for example, they were probably picking and thoroughly chewing one at a time.
I've noticed that when I am foraging, e.g. for wild berries or greens, I tend to chew each one that I pick and eat very, very thoroughly as I search for the next. I think we moderns have largely lost this when eating grocery store food.
Your blender may essentially be doing the same thing, i.e. chewing your food thoroughly for you. I don't necessarily think that this is bad.
One thing to keep in mind is the our digestive system is designed to begin its process in the mouth, where saliva and enzymes start the job. Normally this occurs with chewing. If we swallow a whole smoothie without allowing it to linger in the mouth, we bypass part of the digestive process. Might be more natural to take the smoothie in small amounts and "chew" it a bit in the mouth even though it doesn't really need chewing.
As long as the digestive process is properly started in the mouth, I'm not sure that the stomach and lower GI tract notice any difference between fruit and greens that have been really thoroughly chewed as our primal ancestors would have done, as opposed to some help from a blender.
Fructose is all metabolized in the liver, unlike glucose that can be processed by a wide variety of cells in the body. So too much fruit high in fructose can overload the liver and inhibit its proper function. A moderate amount of fresh fruit doesn't seem to pose a problem. Modern fruit has been selectively cultivated for the highest sugar content. Real primal fruits were undoubtedly generally lower in sugar, but often higher in flavor. A month ago I picked and ate some wild strawberries. Tiny and not super sweet, but the flavor was intense and incredible. The more we can orient toward the sort of fruits that our ancestors probably ate, the better I am sure.