benefit from a spike in insulin and leptin?
Ron_Rosedale_M_D_ 1722 • May 19, 2011 at 9:55 AM link https://www.paleohacks.com/insulin/s...-disagree-5138
The problem with insulin and leptin is not insulin and leptin per se, but insulin and leptin resistance when they cannot get their messages properly heard. The body, and in particular the brain, then responds to high insulin and leptin as if they were low.. I firmly believe that the major cause of both insulin and leptin resistance is repeated spikes in both of those hormones secondary to spikes in blood glucose, so where there might arguably be a short-term benefit from a spike in insulin and leptin, long-term spikes lead to a reduction in signaling, and more importantly a corruption in the where, when, and how the signal is being received by different organs and cell types.
Is this proven regarding Ron's comments "so where there might arguably be a short-term benefit from a spike in insulin and leptin"
Stephen's point is that when people blame insulin for all the evils of world they are generally talking in terms of acute increases in insulin. There is no problems and many benefits of acute spikes in insulin. The problem comes with the CHRONIC elevation of insulin and leptin. To have chronically increased levels of these hormones takes more than just ingesting carbohydrates. It takes a long term hypercaloric state. There a many more factors required to explain a hypercaloric state than JUST carbs ala Taubes. His food reward explanation does a very good job at giving the reasons why we over eat. It comes from an obesity researcher too not a journalist.
Insulin resistance is caused by free fatty acids. It's called the Randle Cycle.
If anyone claims to know what causes leptin resistance in humans, I'm skeptical of them. I have not seen any convincing research on the topic done in humans.
Nothing is ever proven in science. There is simply a preponderance of evidence that tends to favor or not favor a hypothesis. Consensus may be reached by clinicians to make science applicable only to be withdrawn decades later as new evidence arises.
Originally Posted by Kaiibux
Proves my point. Elliot makes a rather strong statement on causality. I don't think we have sufficient evidence supporting his claim. Oxidative stress for one provides a better hypothesis IMO.
Originally Posted by Elliot
And his statement goes against our understanding of this disease state as a multifactoral etiology.
Last edited by Neckhammer; 02-10-2015 at 08:07 AM.
Also, that article is almost 4 years old... Both Stephen and the paleo community at large have come a long way since then.