Does the creation of energy by mitochondria cause free-radicals?
I was doing some reading around chronic inflammation for some study I'm doing at the moment and came across an article that spoke of the release of free-radicals (namely superoxide anion radical) in the creation of ATP by mitochondria.
Inflammation (Chronic) - Mitochondrial Dysfunction , Enzymes, Eicosanoids - Life Extension Health Concern
This also mentions it:
Mitochondrial free radical generation, oxidative stress, and aging. - PubMed - NCBI
Does anyone have any idea if this is important for those trying to get their mitochondria to create more ATP via fatty acid, rather than relying on carbohydrates?
Thanks for your help.
Yes, energy creation by mitochondria does create free radicals. Its a natural process that can be mitigated by a wholesome diet of antioxidants and by more efficient energy creation. Fat is one way to improve energy efficiency. A molecule of fat can yield 129-146 ATP of usable energy, whereas a molecule of glucose yields only 29-32 ATP of usable energy. The chemical process is faster with glucose, but with greater loss of energy in the form of free radicals. The slower burn of fat yields more total energy with fewer free radicals.