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Thread: D-beta-hydroxybutyrate extends lifespan in C. elegans. page

  1. #1
    Chupo's Avatar
    Chupo is offline Member
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    Aug 2012

    D-beta-hydroxybutyrate extends lifespan in C. elegans.

    The ketone body beta-hydroxybutyrate (βHB) is a histone deacetylase (HDAC) inhibitor and has been shown to be protective in many disease models, but its effects on aging are not well studied. Therefore we determined the effect of βHB supplementation on the lifespan of C. elegans nematodes. βHB supplementation extended mean lifespan by approximately 20%. RNAi knockdown of HDACs hda-2 or hda-3 also increased lifespan and further prevented βHB-mediated lifespan extension. βHB-mediated lifespan extension required the DAF-16/FOXO and SKN-1/Nrf longevity pathways, the sirtuin SIR-2.1, and the AMP kinase subunit AAK-2. βHB did not extend lifespan in a genetic model of dietary restriction indicating that βHB is likely functioning through a similar mechanism. βHB addition also upregulated βHB dehydrogenase activity and increased oxygen consumption in the worms. RNAi knockdown of F55E10.6, a short chain dehydrogenase and SKN-1 target gene, prevented the increased lifespan and βHB dehydrogenase activity induced by βHB addition, suggesting that F55E10.6 functions as an inducible βHB dehydrogenase. Furthermore, βHB supplementation increased worm thermotolerance and partially prevented glucose toxicity. It also delayed Alzheimer's amyloid-beta toxicity and decreased Parkinson's alpha-synuclein aggregation. The results indicate that D-βHB extends lifespan through inhibiting HDACs and through the activation of conserved stress response pathways
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  2. #2
    Elliot's Avatar
    Elliot is online now Senior Member
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    Jan 2014
    I would like to see a study comparing the effects on lifespan of a standard diet and a zero-carb ketogenic diet (hopefully in a mammal species, too). I think ketone bodies are good fuel sources but the state in which we produce large amounts of them (ketosis) can be a stressful state. I wonder if the benefits of the ketone bodies can compensate for the stress of carbohydrate restriction.

  3. #3
    Knifegill's Avatar
    Knifegill is offline Senior Member
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    Oct 2010
    Washington state
    Where are the profits in making nematodes live longer?

    Knifegill is christened to be high carb now!
    the buttstuff...never interested.
    He gives me Lamprey Kisses in the midnight sea
    Flubby tubby gums latching onto me
    For all that I've done wrong, I mastodon something right...

    My pony picture thread

  4. #4
    MaceyUK's Avatar
    MaceyUK is offline Senior Member
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    Jun 2013
    Gloucestershire UK
    Nematode vets get paid a fortune. They kept my nematode alive for an extra 3 days and it cost me 980
    Man seeks to change the foods available in nature to suit his tastes, thereby putting an end to the very essence of life contained in them.

  5. #5
    ksecasiup's Avatar
    ksecasiup is offline Junior Member
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    Dec 2014
    Primal Blueprint Expert Certification
    i got it, They kept my nematode alive for an extra 3 days and it cost me 980

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