I'm seeing more and more that too much sitting has a negative impact -- regardless of what you do when you are not sitting. Chris Kresser has info on his site.
I made a New year's resolution to sit less. I now have a stand-up desk at work -- and never sit in my office. I also made a habit of walking around a local track while reading (mostly Kindle) books, checking forums, email, we surfing on tablet.
Lots of sitting together with lots of cycling is double jeopardy on contracting hamstring and calf muscles.