I work on process improvement and new plant design for a large global manufacturer. I do still use Aspen - mainly for design/optimization/troubleshooting of distillation, scrubbing and stripping columns. I usually get (or my team gets) our own thermodynamic data, rather than using the canned Aspen data.
So basically, I make stuff.
Last time I was in Austin, we got up early on Sunday and stood in line for La Barbecue. Good stuff, and free beer while you wait.