Don't put your trust in anyone on this forum, including me. You are the key to your own success.
Last edited by Timthetaco; 12-15-2012 at 11:06 AM.
From Mark's Definitive Guide to Insulin resistance: The Definitive Guide to Insulin, Blood Sugar & Type 2 Diabetes (and you’ll understand it) | Mark's Daily Apple
Over time, as we continue to eat high carbohydrate diets and exercise less, the degree of insulin insensitivity increases. Unless we take dramatic steps to reduce carbohydrate intake and increase exercise, we develop several problems that only get worse over time – and the drugs don’t fix it.
Ready for this? Let’s go:
1) The levels of blood glucose stay higher longer because the glucose can’t make it into the muscle cells. This toxic glucose is like sludge in the bloodstream clogging arteries, binding with proteins to form harmful AGEs (advanced glycated end-products) and causing systemic inflammation. Some of this excess glucose contributes to a rise in triglycerides, increasing risk for heart disease.
2) More sugar gets stored as fat. Since the muscle cells are getting less glycogen (because they are resistant), and since insulin inhibits the fat-burning enzyme lipase, now you can’t even burn stored fat as easily. You continue to get fatter until eventually those fat cells become resistant themselves.
3) It just gets better. Levels of insulin stay higher longer because the pancreas thinks “if a little is not working, more would be better.” Wrong. Insulin is itself very toxic at high levels, causing, among many other maladies, plaque build-up in the arteries (which is why diabetics have so much heart disease) and increasing cellular proliferation in cancers.
4) Just as insulin resistance prevents sugar from entering muscle cells, it also prevents amino acids from entering. So now you can’t build or maintain your muscles. To make matters worse, other parts of your body think there’s not enough stored sugar in the cells, so they send signals to start to cannibalizing your precious muscle tissue to make more – you guessed it – sugar! You get fatter and you lose muscle. Woo hoo!
5) Your energy level drops, which makes you hungry for more carbohydrates and less willing to exercise. You actually crave more of the poison that is killing you.
6) When your liver becomes insulin resistant, it can’t convert thyroid hormone T4 into the T3, so you get those mysterious and stubborn “thyroid problems”, which further slow your metabolism.
7) You can develop neuropathies (nerve damage) and pain in the extremities, as the damage from the excess sugar destroys nerve tissue, and you can develop retinopathy and begin to lose your eyesight. Fun.
8) Eventually, the pancreas is so darn exhausted, it can’t produce any more insulin and you wind up having to inject insulin to stay alive. Lots of it, since you are resistant. Congratulations, you have graduated to insulin-dependent Type 2 diabetes.
Read more: The Definitive Guide to Insulin, Blood Sugar & Type 2 Diabetes (and you’ll understand it) | Mark's Daily Apple
The two main predictors of T2D are high FBG and high HbA1C, both measures of blood glucose, indicating not enough insulin is being secreted to clear the glucose or insulin resistance.
The usual 'remedies' for T2D are 'exercise and eat less'.
I was classified at pre-diabetic several years back. When I started exercising, it made me hungry for the whole-grain, low-fat diet I was prescribed by my CW doc. Only when I ditched almost all carbs and added fat did I see (very drastic) improvement.
So, maybe it has absolutely nothing to do with insulin--just the non-stop glucose ingestion.
There is no doubt in my mind that too much sugar is what caused my fatty liver, high trigs, and pre-diabetes diagnosis. I was a serious sugar-holic. And in my research for a cure, I came across Eades, et al, who say "A potato is a lump of sugar as far as the body is concerned"
Last edited by otzi; 12-15-2012 at 11:19 AM.
If anyone has some credible sources showing that continuous insulin spikes over many years from eating a high carb (processed carbs and in the SAD diet quantities) does not cause those insulin receptors to not hear the insulin signals, with all the issues of high blood sugar/lack of fat mobilisation from cells etc, please post it all here.
To me, the mechanism appears solid.
That does not mean that there is not a place for quality carbs as part of a real food diet, there is, but depending on goals etc, that needs to be carefully dialled in, not a free for all carb-fest
The reason your fasting blood sugar and A1C improved with the high fat diet is because 1) the typical diet prescribed for diabetes is bullshit, and 2) you bypassed your glucose metabolism entirely. I had my diabetic father go on a ketogenic diet and his A1C dropped from 12 to 6. It wasn't because it restored his insulin sensitivity but because he wasn't eating any glucose that could sit around in the blood and cause damage.
I'm not saying that grains and processed foods can't aggravate chronic disease in other ways, but read the study I linked above, or at least the discussion section. If you disagree about the cause of insulin resistance, it would have to be with what causes the increased adiposity in the organs to begin with.Originally Posted by PureFunctionalFitness
Last edited by Timthetaco; 12-15-2012 at 11:24 AM.