DH heard some discussion of this on Reach MD. I keep meaning to go listen to the podcast, but haven't yet. I looked around on the web at primary research and read one paper that described SIRT1 up regulation at 6hrs, maximal expression (2x) at 18 hrs and then a drop at 72 hrs. I dont remeber if it was humans or mice. I didn't save the link since I was only curious. I'm not sure that we know what the impact of various levels of SIRT1 over time will be. Certainly eating as little as possible over as long a stretch as one can manage is more advantageous than 6-8 small meals a day.
CW-125, part calorie counting, part transition to primal
GW- Goals are no longer weight-related