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High fructose intake has been linked to high cholesterol

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  • High fructose intake has been linked to high cholesterol

    There is an interesting piece of research that is being published in the Journal of Nutrition on 1st Aug.

    The study links very high fructose intake with high cholesterol levels

    Fructose, high cholesterol linked in new study | Health, Medical, and Science Updates

    Abstract

    Fructose is widely used as a sweetener in the production of many foods, yet the relation between fructose intake and cholesterol remains uncertain. In this study, we performed a systematic review and meta-analysis of human, controlled, feeding trials involving isocaloric fructose exchange for other carbohydrates to quantify the effects of fructose on serum total cholesterol (TC), LDL cholesterol (LDL-C), and HDL cholesterol (HDL-C) in adult humans. Weighted mean differences were calculated to determine changes from baseline cholesterol concentrations by means of generic, inverse variance, random-effect models. The Heyland Methodological Quality was used to assess the quality of the study. Subgroup analyses and meta-regression were conducted to explore the possible influences of study characteristics. Twenty-four trials (with a total of 474 participants) were included in the meta-analysis. In an overall pooled estimate, it was shown that fructose exerted no effect on HDL-C. Meta-regression analysis indicated that fructose dose was positively correlated with the effect sizes of TC and LDL-C. Subgroup analyses showed that isocaloric fructose exchange for carbohydrates increased TC by 13.0 mg/dL [(95% CI: 4.7, 21.3); P = 0.002] and LDL-C by 11.6 mg/dL [(95% CI: 4.4, 18.9); P = 0.002] at >100 g fructose/d. However, no effect was shown on TC or LDL-C when the fructose intake was ≤100 g/d. In conclusion, it was shown that very high fructose intake (>100 g/d) increases serum LDL-C and TC concentrations. Larger, longer, and higher-quality human, controlled, feeding trials are needed to confirm these results.
    Be who you are and say what you feel, because those who mind don't matter and those who matter don't mind.

    Dr. Seuss

  • #2
    it was shown that very high fructose intake (>100 g/d) increases serum LDL-C and TC concentrations.
    Wait, are you saying three Mountain Dews per day is too much?! OMG!

    Now they should try it with fruit sources instead.
    Crohn's, doing SCD

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    • #3
      Originally posted by Knifegill View Post
      Wait, are you saying three Mountain Dews per day is too much?! OMG!

      Now they should try it with fruit sources instead.
      This seems to be the case for most research touting the "dangers" of fructose. Of course excessive amounts of fructose can cause harm. The same could be said for anything. <100g per day of pure fructose is a ridiculous amount that almost no one ever consumes in a single day.
      My nutrition/fitness/critical thinking blog:

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      • #4
        Originally posted by jakejoh10 View Post
        This seems to be the case for most research touting the "dangers" of fructose. Of course excessive amounts of fructose can cause harm. The same could be said for anything. <100g per day of pure fructose is a ridiculous amount that almost no one ever consumes in a single day.
        High fructose corn syrup contains therefore from 50% to 80% fructose. A 20oz Mountain Dew contains 77g of carbs. Three a day contain 77g x 3 = 231g of sugar, which can range from 115.5 to 184.8g of pure fructose. I'm trying to figure out how that's not unhealthy, since it is hardly unknown for people who like it to drink three 20oz bottles of Mountain Dew in a day.

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        • #5
          I used to drink 2 liters of soda almost every day. Either a generic orange flavor or Mountain Dew. I know for sure that was above and beyond any safe threshold for fructose consumption.
          Crohn's, doing SCD

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          • #6
            Mmmm code red.

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            • #7
              Originally posted by Knifegill View Post
              I used to drink 2 liters of soda almost every day. Either a generic orange flavor or Mountain Dew. I know for sure that was above and beyond any safe threshold for fructose consumption.
              3 liter a day? Whoa!
              Few but ripe.

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              • #8
                Originally posted by eKatherine View Post
                High fructose corn syrup contains therefore from 50% to 80% fructose. A 20oz Mountain Dew contains 77g of carbs. Three a day contain 77g x 3 = 231g of sugar, which can range from 115.5 to 184.8g of pure fructose. I'm trying to figure out how that's not unhealthy, since it is hardly unknown for people who like it to drink three 20oz bottles of Mountain Dew in a day.
                You've done it again Katherine. I have no idea what you're talking about, and I never said anything about there's anything healthy about drinking three 20oz bottles of Mountain Dew per day. You should really start reading people's posts instead of making strawman arguments and putting words in people's mouths.

                The studies that most people cite claiming that fructose (even high fructose corn syrup) are stupid and sensationalist. That is my point. Everyone knows that guzzling soda like it's water is not healthy. There's nothing ground-breaking or exciting about this. How people conclude that fructose is poison just because some studies administer the consumption of abnormal amounts of pure fructose is beyond my comprehension.
                My nutrition/fitness/critical thinking blog:

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                • #9
                  Originally posted by jakejoh10 View Post
                  This seems to be the case for most research touting the "dangers" of fructose. Of course excessive amounts of fructose can cause harm. The same could be said for anything. <100g per day of pure fructose is a ridiculous amount that almost no one ever consumes in a single day.
                  Actually... eKatherine was pointing out that it is a very normal amount of consumption for "soda drinkers".

                  There is really nothing at all abnormal about a soda drinker having 3 20oz sodas a day, which was the number she tallied up.
                  “You have your way. I have my way. As for the right way, the correct way, and the only way, it does not exist.”
                  ~Friedrich Nietzsche
                  And that's why I'm here eating HFLC Primal/Paleo.

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                  • #10
                    Originally posted by cori93437 View Post
                    Actually... eKatherine was pointing out that it is a very normal amount of consumption for "soda drinkers".

                    There is really nothing at all abnormal about a soda drinker having 3 20oz sodas a day, which was the number she tallied up.
                    You're right. What I meant to say was that no one is arguing that this amount of fructose (or high fructose corn syrup) consumption is healthy. My point is that all of the studies claiming that fructose is dangerous is having people consume amounts of fructose that we know is unhealthy; it's obvious. So, claiming that fructose is dangerous at excessive amounts is no secret, but what irks me is that people tend to take studies like this and claim that fructose is toxic no matter the dose, which is obviously false.
                    My nutrition/fitness/critical thinking blog:

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                    • #11
                      Originally posted by jakejoh10 View Post
                      You're right. What I meant to say was that no one is arguing that this amount of fructose (or high fructose corn syrup) consumption is healthy. My point is that all of the studies claiming that fructose is dangerous is having people consume amounts of fructose that we know is unhealthy; it's obvious. So, claiming that fructose is dangerous at excessive amounts is no secret, but what irks me is that people tend to take studies like this and claim that fructose is toxic no matter the dose, which is obviously false.
                      I got what you meant. You were pretty much saying that most people who eat whole food sources of fructose, like fruit, are usually not consuming more than 100g/day or whatever threshold where it becomes unhealthy. HFCS soda is pure crap and easy to reach harmful levels with it. Let's see a study done with fruit and all other whole foods. Do we really need to further investigate if soda made with HFCS is unhealthy?
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                      • #12
                        Soda made on HFCS can easily be unhealthy, but it's not that much difference from the old school soda made on sucrose though? Sucrose is 50% glucose and 50 % fructose while HFCS is 45% glucose and 55 % fructose if I remember correctly?
                        "All truth passes through three stages. First, it is ridiculed. Second, it is violently opposed. Third, it is accepted as being self-evident."

                        - Schopenhauer

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                        • #13
                          Originally posted by j3nn View Post
                          I got what you meant. You were pretty much saying that most people who eat whole food sources of fructose, like fruit, are usually not consuming more than 100g/day or whatever threshold where it becomes unhealthy. HFCS soda is pure crap and easy to reach harmful levels with it.
                          Yes, exactly . I really need to start organizing my thoughts before I hit the post button lol.
                          My nutrition/fitness/critical thinking blog:

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                          • #14
                            That's great news. Because cholesterol is essential for life, right?

                            Seriously though, high dose isolated fructose studies are pretty irrelevant. If someone is drinking several litres of soda a day I doubt they would be alarmed to hear that it could be contributing to ill health.
                            Last edited by Forgotmylastusername; 07-08-2013, 01:22 AM.

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                            • #15
                              They would be alarmed. I was. I was taught soda was "not good" for me, I didn't know that it "is bad" for me. "Not good" is a lot different than "is bad". In true poverty, the mysticism around packaged food is strong. We just assume they put all the vitamins and other stuff in there for us.
                              Crohn's, doing SCD

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