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High Carb Diet = Cancer?

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  • High Carb Diet = Cancer?

    [quote]

    Two major conclusions emerge from the hypothesis; first that many cancers can regress if energy intake is restricted and, second, that many cancers can be prevented if energy intake is restricted. Consequently, energy restricted diets combined with drugs targeting glucose and glutamine can provide a rational strategy for the longer term management and prevention of most cancers.
    </blockquote>


    Full Text (PDF): http://2.ly/huy

    “Every saint has a past and every sinner has a future.” -Oscar Wilde
    "The power of accurate observation is commonly called cynicism by those who have not got it." -George Bernard Shaw
    "The trouble with jogging is that the ice falls out of your glass." -Martin Mull

  • #2
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    Nora Gedgoudas has a similar discussion about this in her book, "Primal Body-Primal Mind".

    “It is a truism that almost any sect, cult, or religion will legislate its creeds into law if it acquires the political power to do so, and will follow it by suppressing opposition, subverting all education to seize early the minds of the young, and by killing, locking up, or driving underground all heretics.”
    —Robert A. Heinlein

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    • #3
      1



      SS, your quote says nothing about carbs at all. It says restricting energy intake is important...as in how much food you eat.

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      • #4
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        I presume the bit about "drugs targeting glucose..." is the clincher?

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        • #5
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          The quote SS chose doesn&#39;t mention carbs, but the paper provides more detail, arguing that cancer cells are almost always glucose-dependent, and cannot run on fatty acids like most normal cells can.


          I suspect the authors focused more on the calorie-restricted diets in the paper because there&#39;s a lot more data on those. However, the authors&#39; research program focuses on the use of ketogenic diets to complement cancer therapy, so perhaps we&#39;ll be hearing more about that in the future.


          He does admit somewhere in that paper that the calorie-restricted diets that have been shown effective in rats would be the equivalent of 500-600 calorie per day diets for humans. That might be impossible for most humans, but a bit higher wouldn&#39;t be very difficult as long as one went very low carb.

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          • #6
            1



            Article also mentioned that ketone energy source protects mitochondria. So that sound to me like fat based energy is preferred over carb based glucose energy.

            “It is a truism that almost any sect, cult, or religion will legislate its creeds into law if it acquires the political power to do so, and will follow it by suppressing opposition, subverting all education to seize early the minds of the young, and by killing, locking up, or driving underground all heretics.”
            —Robert A. Heinlein

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            • #7
              1



              Caloric restriction in a high carb diet = lower glucose, but as some mentioned before, a low-carb ketogenic diet would prevent starvation while lowering glucose, probably even more than a calorie-restricted high-carb diet + drugs.


              There are also lot&#39;s of papers suggesting ketogenic diets as a metabolic treatment for ongoing cancers. It&#39;s just a matter of connecting the dots...

              “Every saint has a past and every sinner has a future.” -Oscar Wilde
              "The power of accurate observation is commonly called cynicism by those who have not got it." -George Bernard Shaw
              "The trouble with jogging is that the ice falls out of your glass." -Martin Mull

              Comment


              • #8
                1



                Low calorie diets is a common trait of the "Blue Zones."


                Cutting the the refined carbs and sugars would also be a logical first step in reducing energy intake.

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                • #9
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                  http://high-fat-nutrition.blogspot.com/search/label/Cancer%20and%20ketones


                  I don&#39;t have the study at hand, but...


                  Apparently low calorie ketosis (ZC) works very well for brain cancer. The cancer can&#39;t get any glucose to survive in the skull. I don&#39;t think it works as well elsewhere in the body as the cancer can feed off of surrounding glucose (which isn&#39;t as available in the brain).


                  There was a study done with brain cancer patients that were out of options. They had already undergone radiotheraphy/chemotherapy.

                  They were put on a low calorie ZC diet and it saved some of them.


                  A large percentage of the study group gave up on the diet and died.

                  The "Seven Deadly Sins"

                  • Grains (wheat/rice/oats etc) . . . . . • Dairy (milk/yogurt/butter/cheese etc) . . . . .• Nightshades (peppers/tomato/eggplant etc)
                  • Tubers (potato/arrowroot etc) . . . • Modernly palatable (cashews/olives etc) . . . • Refined foods (salt/sugars etc )
                  • Legumes (soy/beans/peas etc)

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                  • #10
                    Yes, there's mounting evidence that high carb, especially high fructose in an unnatural form, raises risk of cancers.

                    Cancer causes: 'Healthy' fruit juice has so much sugar it could bring on tumours | Mail Online

                    Fructose is about 100 times as mutagenic as glucose (mutagenic means damaging to DNA - and DNA mutations are a major contributing cause of cancer). When it's consumed in the form of white sugar and HFCS and even large amounts of fruit juices, it's absorbed sufficiently quickly that the liver becomes overloaded in detoxing it from the body. The liver is a powerhouse of the immune system so when it's preoccupied with detoxing fructose it has to cease assisting the immune system eliminate cancerous or pre-cancerous cells from the body.

                    Glucose is also problematic when blood glucose goes too high on a regular basis. A high-carb low-fat diet, especially alongside a sedentary lifestyle, eventually will cause insulin resistance and raised blood glucose levels.

                    It's been shown that some cancer cells begin to start expressing genes for fructose transporters so that they can guzzle up fructose from the blood stream:

                    Cancer cells slurp up fructose, US study finds | Reuters

                    There's evidence for breast, colon and pancreatic cancer cells doing this.

                    Note: normally only liver cells take up fructose so it can be detoxed to fat or glucose. If it's detoxed to fat (which is pretty much guaranteed when glucose is abundant) that's predominantly to the saturated fatty acid palmitic acid that has been shown to contribute to insulin resistance (note that palmitic acid is unlikely to be be produced in excess in a primal low/moderate carb diet and it's only present in low amounts in most primal foods):

                    JCI - Palmitic acid mediates hypothalamic insulin resistance by altering PKC-&#x003b8; subcellular localization in rodents
                    Last edited by paleo-bunny; 02-29-2012, 01:29 PM. Reason: grammar
                    F 5 ft 3. HW: 196 lbs. Primal SW (May 2011): 182 lbs (42% BF)... W June '12: 160 lbs (29% BF) (UK size 12, US size 8). GW: ~24% BF - have ditched the scales til I fit into a pair of UK size 10 bootcut jeans. Currently aligning towards 'The Perfect Health Diet' having swapped some fat for potatoes.

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                    • #11
                      [QUOTE=SerialSinner;58382]

                      Two major conclusions emerge from the hypothesis; first that many cancers can regress if energy intake is restricted and, second, that many cancers can be prevented if energy intake is restricted. Consequently, energy restricted diets combined with drugs targeting glucose and glutamine can provide a rational strategy for the longer term management and prevention of most cancers.
                      </blockquote>


                      Full Text (PDF): http://2.ly/huy
                      Conditioning Research: fasting ...cancer...we have heard this before?

                      Comment


                      • #12
                        Originally posted by SerialSinner View Post
                        Two major conclusions emerge from the hypothesis; first that many cancers can regress if energy intake is restricted and, second, that many cancers can be prevented if energy intake is restricted. Consequently, energy restricted diets combined with drugs targeting glucose and glutamine can provide a rational strategy for the longer term management and prevention of most cancers.
                        IMO, this is the kidney/protein argument.

                        If you have bad kidneys, you cannot eat a high protein diet. However, this does not mean high protein diets hurt kidneys. High protein diets are only dangerous if your kidneys have been damaged from an outside source. It is not the fault of the protein.

                        If you have cancer, a ketogenic diet that eliminates glucose can be highly beneficial since cancer feeds on sugar. However, that doesn't mean sugar gives you cancer. A ketogenic diet should be done for two reasons: specific medicinal needs or you have no other food availability. The ideal human diet, IMO, contains lots of animal fat, lots of starch and moderate amounts of fruit sugar (not isolated - eat the whole fruit).

                        I strongly, strongly doubt people are getting cancer from eating sweet potatoes, bananas, apples, white rice and cassava. In fact, I'm so sure, I'm betting my life on it because I eat those things all the time. Almost daily. Now, wheat, soy, omega 6 vegetable oils, poorly cooked or uncooked legumes, HFCS/agave syrup and chemical sweeteners, artificial flavors, chemical thickeners/emulsifiers and food colorings? I'm willing to bet they cause cancer. Guess what? I avoid all those things like the plague. I'll sooner shovel 5 lbs of sweet potatoes down my throat before I eat a single tablespoon of soybean oil. I don't give a damn if it's extra virgin cold-pressed soybean oil or superheated, chemically-extracted soybean oil. Keep it away from me.

                        My opinion.
                        Don't put your trust in anyone on this forum, including me. You are the key to your own success.

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                        • #13
                          Well I can see you're all chemists,nutritionists,scientists.....

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                          • #14
                            Yup everyone thousands of years ago was getting cancer with all the wheat they were eating. For some reason. Maybe it was the "anti nutrients"?

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                            • #15
                              ketosis an be therapeutic for cancer or for epilepsy. doesn't mean we all need to hurry up and get into ketosis or we're going to become epileptic.

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