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Vitamin D potentially influences wide range of gene expression

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  • Vitamin D potentially influences wide range of gene expression

    New article from Science Daily summarizing results published in Genome Research.

    There are a couple of interesting points.
    1. Vitamin D receptor proteins directly influence over 200 genes.
    Scientists have mapped the points at which vitamin D interacts with our DNA -- and identified over two hundred genes that it directly influences.
    2. The receptor sites are clustered around loci with known auto-immune associations.
    The researchers found 2,776 binding sites for the vitamin D receptor along the length of the genome. These were unusually concentrated near a number of genes associated with susceptibility to autoimmune conditions such as MS, Crohn's disease, systemic lupus erythematosus (or 'lupus') and rheumatoid arthritis, and to cancers such as chronic lymphocytic leukaemia and colorectal cancer.
    This is highly speculative research, but sets a foundation for more focused research on how vitamin D may confer protection against some classes of disease. Plus, it's suggestive as hell.