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Is fructose bad for brain inflammation?

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  • #31
    [QUOTE=Derpamix;1183916]Sigh. monosaccharides, like fructose, are converted to entry points of glycolysis through ingesting the substance. [QUOTE]

    Fructose can enter at the Fructose 6 point:
    http://www.biocarta.com/pathfiles/feederpathway.asp

    But,
    Still don't know what you're trying to say, how does that differ to any sugar ingested or to endogenously created glucose through gluconeogenesis?

    Same starting point, same end products.

    None of this means eating an apple, fructose will go straight to your brain and prevent convulsions.
    Last edited by Omni; 05-07-2013, 11:36 PM.
    "There are no short cuts to enlightenment, the journey is the destination, you have to walk this path alone"

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    • #32
      Originally posted by Omni View Post

      Fructose can enter at the Fructose 6 point:
      BioCarta - Charting Pathways of Life

      But,
      Still don't know what you're trying to say, how does that differ to any sugar ingested or to endogenously created glucose through gluconeogenesis?

      Same starting point, same end products.

      None of this means eating an apple, fructose will go straight to your brain and prevent convulsions.
      That works both ways, no? The topic is "is fructose bad for brain inflammation", no, no it is not.

      Did you read the study?

      Because fructose-1,6-bisphosphate (F1,6BP) shifts the metabolism of glucose from glycolysis to the pentose phosphate pathway, it was hypothesized to have anticonvulsant activity.
      It's different in that the only way around specific glucose malfunctioning pathways is via fructose or ketones, as stated in my original post, I think. Been a long time since then.

      As for gluconeogenesis

      http://www.pearsonhighered.com/mathews/ch16/fi16p6.htm
      Last edited by Derpamix; 05-07-2013, 11:52 PM.
      Make America Great Again

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      • #33
        You're drawing conclusions that aren't available in the study quoted.
        Fructose was not studied,
        By injecting an intemediary into the relevant tissue simply shifts the equilibrium of the process and this may well have an anti convulsive effect and the elimination of the first 3 steps may be a clue as to the problem, but in no way does it suggest fructose is the answer and that fructose prevents convulsions.

        If they thought this was the case the study would be simple feed one group of rats glucose and feed the others fructose see which ones have convulsions.

        To OP, a bit of sugar in your kefir is no problems, enjoy it.
        Last edited by Omni; 05-08-2013, 12:09 AM.
        "There are no short cuts to enlightenment, the journey is the destination, you have to walk this path alone"

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        • #34
          Originally posted by Omni View Post
          You're drawing conclusions that aren't available in the study quoted.
          Fructose was not studied,
          By injecting an intemediary into the relevant tissue simply shifts the equilibrium of the process and this may well have an anti convulsive effect and the elimination of the first 3 steps may be a clue as to the problem, but in no way does it suggest fructose is the answer and that fructose prevents convulsions.

          If they thought this was the case the study would be simple feed one group of rats glucose and feed the others fructose see which ones have convulsions.

          To OP, a bit of sugar in your kefir is no problems, enjoy it.
          They wanted to stimulate the pentose phosphate pathway which has already been extensively studied, this is what the experiment was about.

          And, it sort of does suggest that? It's absolutely not fool proof, but nothing is.

          I'm hypothesizing.

          Anyway, thanks for making this topic more interesting, but I'm tired as hell, so I'm going to sleep. Night, Omni.
          Make America Great Again

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          • #35
            Goodnight, sleep tight, don't let the bed bugs bite.
            "There are no short cuts to enlightenment, the journey is the destination, you have to walk this path alone"

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            • #36
              Originally posted by Paleobird View Post
              There is a big difference between slurping down a diet high in HFCS and having an occasional kefir.
              That @paleobird. I have a lot of kefir, basically drinking it in place of water during the day. Especially the ginger ale and raspberry kefir are so very good.

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              • #37
                Originally posted by Omni View Post
                Goodnight, sleep tight, don't let the bed bugs bite.
                Thanks, I slept very well.

                I would be more concerned about the questionable effects of consuming lots of probiotics than anything else.
                Make America Great Again

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                • #38
                  Originally posted by Derpamix View Post
                  Thanks, I slept very well.

                  I would be more concerned about the questionable effects of consuming lots of probiotics than anything else.
                  Well, I see what you mean, having thought the same thing re probiotics. BUT I am clockwork regular and have been feeling great and don't feel that the probiotics are too much, so far at least. I sat this a.m. and read through most of the discussions in this thread. Clearly others like you know way more than I, but I will keep reading. How much IS too much re probiotics?

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                  • #39
                    Originally posted by Aili View Post
                    Well, I see what you mean, having thought the same thing re probiotics. BUT I am clockwork regular and have been feeling great and don't feel that the probiotics are too much, so far at least. I sat this a.m. and read through most of the discussions in this thread. Clearly others like you know way more than I, but I will keep reading. How much IS too much re probiotics?
                    Fermented foods and probiotics increase lactic acid, which your body already produces enough of as a stress reaction, and too much can cause a burden on the liver. In an inflamed digestive tract, introducing foreign bacteria could make things worse. Pay attention for signs of bloating, or stomach discomfort. If you feel great, it's probably OK for now.

                    Is it just the taste you like re: kefir, or are you eating it for the "benefits"?
                    Make America Great Again

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                    • #40
                      Is it just the taste you like re: kefir, or are you eating it for the "benefits"?[/QUOTE]

                      Thanks for the quick reply. I like it for the cold pop-like fizziness, combined with the fact that it is made of a few natural ingredients (use only organic sugar, berries from our land, and ginger at times, and no HFCS, chemicals, dyes, etc.) and that it has the probiotic benefits. I first came across it when I was looking for something that could replace my occasional craving for carbonation. I don't drink pop of any kind and did get carbonated water once in a while, and kefir is a great alternative to buying the water.

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                      • #41
                        That's cool, yeah, it does taste pretty good. Perhaps if you get a soda stream and add co2 to the kefir it could offset some of the lactate from fermentation. Just a thought.

                        Soda stream will also allow you to have even more variety for fizzy stuff!
                        Make America Great Again

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                        • #42
                          Originally posted by Derpamix View Post
                          That's cool, yeah, it does taste pretty good. Perhaps if you get a soda stream and add co2 to the kefir it could offset some of the lactate from fermentation. Just a thought.

                          Soda stream will also allow you to have even more variety for fizzy stuff!
                          Well, what I do is, after the first ferment (usually 2 days with loose top for breathing), with just a bit of sweetness (fructose, aka topic begun here), I put it with fruit or ginger in a closed top for a second ferment for about 1 day, then into those green beer bottles with the ceramic and rubber tops, and into the fridge. What emerges is a really cold and fizzy drink, no need for extra carbonation. A chef who visited a few days ago said the ginger ale was the best she has ever had. It really is quite addicting.
                          edit: The raspberry kefir is like champagne when I get it right.
                          Last edited by Aili; 05-08-2013, 08:46 AM.

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                          • #43
                            Originally posted by Derpamix View Post
                            Fermented foods and probiotics increase lactic acid, which your body already produces enough of as a stress reaction, and too much can cause a burden on the liver.
                            Everything makes so much sense now. Thank you for the enlightenment
                            My chocolatey Primal journey

                            Unusual food recipes (plus chocolate) blog

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                            • #44
                              Originally posted by Derpamix View Post
                              Fermented foods and probiotics increase lactic acid, which your body already produces enough of as a stress reaction, and too much can cause a burden on the liver. In an inflamed digestive tract, introducing foreign bacteria could make things worse. Pay attention for signs of bloating, or stomach discomfort. If you feel great, it's probably OK for now.

                              Is it just the taste you like re: kefir, or are you eating it for the "benefits"?
                              Glad you slept well,
                              Are we there again?

                              I assume you are refering to D Lactate, which is an issue in significant quantities and generally in the case of GI damage and microbiota imbalance.
                              L Lactate is as natural to the body as Glucose
                              "There are no short cuts to enlightenment, the journey is the destination, you have to walk this path alone"

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                              • #45
                                No, to decrease inflammation you want to ditch the PUFAs and starches, not fructose.

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