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Is fructose bad for brain inflammation?

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  • #16
    Originally posted by Paleobird View Post
    Once again F1, 6BP=/=fructose
    ...What? fructose-6-phosphate is fructose phosphorylated on 6 carbon, using magnesium as a cofactor for phosphofructokinase, it converts that into fructose 1'6-b

    It is fructose... These are the various pathways I was talking about.
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    • #17
      Originally posted by cori93437 View Post
      Yeah... I just finished reading. That isn't JUST fructose.
      Try talking to a specialist in the field about it... sugars, even fructose (from eating fruit) in large doses can cause problems with inflammation/anti-inflammatory cascades and neuro-excitability that is bad news.
      Derp, don't try to tell Cori and I (one with an inflammatory brain condition and one with epilepsy) that we don't know what we are talking about when it comes to sugar and the brain.

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      • #18
        Once again... folks with normal brains, pretty much the lot of you, enjoy your sugars from whole natural foods. YUM.

        But, folks with brain issues, maybe consult an actual doctor (i.e. specialist in the field of your brain issue) and deal with your own particular situation via that route and some n=1!
        I personally can have some bad results from over consuming any sugars... be it glucose, fructose, or similarly acting alcohol.
        However I still indulge a bit on occasion...

        Weeeeeeeeeeeeeeeee!

        "Not all of the people, not all of the time."
        ^^One of my favorite quotes from an old prof of mine.
        Most things fit in that bin.
        “You have your way. I have my way. As for the right way, the correct way, and the only way, it does not exist.”
        ~Friedrich Nietzsche
        And that's why I'm here eating HFLC Primal/Paleo.

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        • #19
          Originally posted by Derpamix View Post
          ...What? fructose-6-phosphate is fructose phosphorylated on 6 carbon, using magnesium as a cofactor for phosphofructokinase, it converts that into fructose 1'6-b
          It is fructose... These are the various pathways I was talking about.
          It's not fructose. It's a byproduct of glycolysis.
          Glycolysis literally means "splitting sugars." See step 3.

          10 Steps of Glycolysis

          Step 1
          The enzyme hexokinase phosphorylates (adds a phosphate group to) glucose in the cell's cytoplasm. In the process, a phosphate group from ATP is transferred to glucose producing glucose 6-phosphate.

          Step 2
          The enzyme phosphoglucoisomerase converts glucose 6-phosphate into its isomer fructose 6-phosphate. Isomers have the same molecular formula, but the atoms of each molecule are arranged differently.

          Step 3
          The enzyme phosphofructokinase uses another ATP molecule to transfer a phosphate group to fructose 6-phosphate to form fructose 1, 6-bisphosphate.

          Step 4
          The enzyme aldolase splits fructose 1, 6-bisphosphate into two sugars that are isomers of each other. These two sugars are dihydroxyacetone phosphate and glyceraldehyde phosphate.

          Step 5
          The enzyme triose phosphate isomerase rapidly inter-converts the molecules dihydroxyacetone phosphate and glyceraldehyde phosphate. Glyceraldehyde phosphate is removed as soon as it is formed to be used in the next step of glycolysis.

          Step 6
          The enzyme triose phosphate dehydrogenase serves two functions in this step. First the enzyme transfers a hydrogen (H-) from glyceraldehyde phosphate to the oxidizing agent nicotinamide adenine dinucleotide (NAD+) to form NADH. Next triose phosphate dehydrogenase adds a phosphate (P) from the cytosol to the oxidized glyceraldehyde phosphate to form 1, 3-bisphosphoglycerate. This occurs for both molecules of glyceraldehyde phosphate produced in step 5.

          Step 7
          The enzyme phosphoglycerokinase transfers a P from 1,3-bisphosphoglycerate to a molecule of ADP to form ATP. This happens for each molecule of 1,3-bisphosphoglycerate. The process yields two 3-phosphoglycerate molecules and two ATP molecules.

          Step 8
          The enzyme phosphoglyceromutase relocates the P from 3-phosphoglycerate from the third carbon to the second carbon to form 2-phosphoglycerate.

          Step 9
          The enzyme enolase removes a molecule of water from 2-phosphoglycerate to form phosphoenolpyruvic acid (PEP). This happens for each molecule of 2-phosphoglycerate.

          Step 10
          The enzyme pyruvate kinase transfers a P from PEP to ADP to form pyruvic acid and ATP. This happens for each molecule of PEP. This reaction yields 2 molecules of pyruvic acid and 2 ATP molecules.

          source:10 Steps of Glycolysis

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          • #20
            Originally posted by Paleobird View Post
            Derp, don't try to tell Cori and I (one with an inflammatory brain condition and one with epilepsy) that we don't know what we are talking about when it comes to sugar and the brain.
            Perhaps you think sugar is bad for your brain, but you didn't provide any evidence to show it's bad for the brain in general. I even explained how sugar could harm people under certain situations. Those with impaired glucose pathways won't do well eating just glucose all at once, but fructose is something different.

            There is more than one way to fix every problem, the human body is amazingly resourceful.

            And I'll stop saying you don't know what you're talking about when you stop trying to belittle my intelligence and call me stupid at every turn.
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            • #21
              Originally posted by Paleobird View Post
              It's not fructose. It's a byproduct of glycolysis.
              Glycolysis literally means "splitting sugars." See step 3.

              source:10 Steps of Glycolysis
              Yeah, I know, how does it make it "not fructose" again? To split a sugar, in this case, fructose, doesn't it have to be a sugar in the first place? Or are you saying this is created fructose from the body?
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              • #22
                Originally posted by cori93437 View Post
                Once again... folks with normal brains, pretty much the lot of you, enjoy your sugars from whole natural foods. YUM.

                But, folks with brain issues, maybe consult an actual doctor (i.e. specialist in the field of your brain issue) and deal with your own particular situation via that route and some n=1!
                I personally can have some bad results from over consuming any sugars... be it glucose, fructose, or similarly acting alcohol.
                Exactly. One of the posters in my epilepsy thread has had two seizures recently both after an over indulgence in sweets. I had a pre-seizure aura a few nights ago after a drink and dessert indulgence added on to dinner.

                Derp, I know Peat thinks fructose is some kind of holy water but it's not. And F1,6BP is not fructose.

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                • #23
                  Originally posted by Paleobird View Post
                  And F1,6BP is not fructose.
                  Really? Because my high school biology textbook shows that fructose 1,6 bisphosphate is part of the d-fructose isomer family.

                  Go ahead and read this:

                  http://upload.wikimedia.org/wikipedi..._reactions.png

                  It's one of the various metabolic pathways of fructose. After looking at that, go ahead and explain how it's not a possible derivative of ingesting fructose.
                  Last edited by Derpamix; 05-07-2013, 10:40 PM.
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                  • #24
                    Originally posted by Derpamix View Post
                    Really? Because my high school biology textbook shows that fructose 1,6 bisphosphate is part of the d-fructose isomer family.
                    My sister's husband's third cousin's father in law's daughter is a member of my family but that doesn't mean we are anything alike.

                    Fructose like you get from eating fruit=/=F1,6 BP even though the F does stand for fructose. Chemically different beasts.

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                    • #25
                      Originally posted by Paleobird View Post
                      My sister's husband's third cousin's father in law's daughter is a member of my family but that doesn't mean we are anything alike.

                      Fructose like you get from eating fruit=/=F1,6 BP even though the F does stand for fructose. Chemically different beasts.
                      How many different meanings do you think something as not vague as F1,6 BP do you think there are? I already told you what it is, what it does, showed you how it's made, how it's related to glycolysis; and even asked you to explain how it's created without fructose. Wtf is it even? Some mystery function created from nothing? It's just there, magically, in your body. Or is this something evil scientists created?

                      Can't you just admit you're wrong? No one will think less of you, honestly.
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                      • #26
                        Originally posted by Derpamix View Post
                        How many different meanings do you think something as not vague as F1,6 BP do you think there are? I already told you what it is, what it does, showed you how it's made, how it's related to glycolysis; and even asked you to explain how it's created without fructose. Wtf is it even? Some mystery function created from nothing? It's just there, magically, in your body. Or is this something evil scientists created?
                        No, it's a byproduct of glycolysis. Not magic. But also not fructose.
                        Derpy, it was an interesting article about an interesting substance that acts much in the same way as ketosis for neuroprotectivity but it was not about fructose from eating a piece of fruit. Sorry, you're beating dead horses here.

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                        • #27
                          Maybe a picture will show it better
                          File:Glycolysis2.svg - Wikipedia, the free encyclopedia
                          4th molecule on the top pathway
                          "There are no short cuts to enlightenment, the journey is the destination, you have to walk this path alone"

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                          • #28
                            Originally posted by Omni View Post
                            Maybe a picture will show it better
                            File:Glycolysis2.svg - Wikipedia, the free encyclopedia
                            4th molecule on the top pathway
                            Thanks, Omni. That is the pictorial version of the 10 steps of glycolysis I posted upthread. Helpful to have both.

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                            • #29
                              Originally posted by Paleobird View Post
                              No, it's a byproduct of glycolysis. Not magic. But also not fructose.
                              Derpy, it was an interesting article about an interesting substance that acts much in the same way as ketosis for neuroprotectivity but it was not about fructose from eating a piece of fruit. Sorry, you're beating dead horses here.
                              Sigh. monosaccharides, like fructose, are converted to entry points of glycolysis through ingesting the substance.

                              Glycolysis itself is just a metabolic pathway for conversion of glucose into pyruvate used in process of creating ATP.

                              It's all here:

                              File:Glycolysis2.svg - Wikipedia, the free encyclopedia

                              I guess all that was needed was to explain what glycolysis actually is to you.
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                              • #30
                                Originally posted by Derpamix View Post
                                Sigh. monosaccharides, like fructose, are converted to entry points of glycolysis through ingesting the substance.

                                Glycolysis itself is just a metabolic pathway for conversion of glucose into pyruvate used in process of creating ATP.

                                It's all here:

                                File:Glycolysis2.svg - Wikipedia, the free encyclopedia
                                Yeah, Derp. Omni just posted that same file. Look up there^^^.

                                Taking the chemical compound found in step three of the ten steps of glycolysis and isolating it and experimenting on rat brains with it is very interesting. But it has zero to do with ingesting fructose.

                                Glycolysis starts with glucose, a different monosaccharide entirely.

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