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Leptin Reset Experiment starts today - Jack Kruse style

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  • I got extreme anxiety on the evening of the first day.

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    • Originally posted by DigitalSurgeon View Post
      Leptin is available ot research protocols in synthetic form. It is not suitable for public use because the Amgen trials did not show success in a large enough cross section of patients. The one place where it was extremely successful was in the morbidly obese who lost weight by themselves or with surgery. The reason is the morbidly obese destroy their hypocretin neurons in the hypothalamus and this reduces the sensitivity to leptin. So the previously fat person need higher leptin levels to stimulate the smaller amount of neurons in the brain. When these people were given synthetic leptin they did very well. I think eventually leptin will be released as an adjunct to obesity surgery.
      Oh goody, so even if we lose weight and get healthy, we're stuck with this problem?
      Gluten intolerance and hypermobility syndrome http://www.cfids.org/pdf/joint-hypermobility-guide.pdf

      Eat food. Mostly real. Enjoy life.

      Health, energy, wellbeing, vitality, joy, LIFE! Health At Every Size

      "Do not ask what the world needs; ask yourself what makes you come alive. And then go and do that, because what the world needs is people who have come alive."
      Harold Whitman

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      • Granted my brain hasn't been working well lately, but my reading of that was that taking synthetic leptin supplements wasn't showing itself to be "the answer" for most people, similar to how synthetic hormones haven't been the answer for post-menopausal HRT or thyroid patients, etc. But my guess is that natural leptin supplementation, if it can be developed, or dietary changes, will be the best answer - as in those same other hormonal cases. Dunno if I'm right!
        5'4" 39yo mother to five sweeties & married to their AMAZING DaddyGrok
        Current Weight: 175lb__________________________________Goal: 135lb
        Deadlift: 240lb________________________________________Back Squat: 165lb
        Bench: 130lb__________________________________________Pre ss: 85lb
        ***Winning a 20-year war against binge eating disorder***

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        • Originally posted by wylde_child View Post
          Has anyone else been having issues with anxiety during the reset? For the last 2 to 3 days I've been easily startled and right now I feel terribly anxious and jittery. It feels like my adrenals are working overtime. I've been doing the reset for about 2 1/2 weeks.
          Not actual anxiety, but I've definitely been short tempered and "off". Not as sharp as normal and just feeling a bit blue. I'm sticking it out, as everything I read leads me to believe that I'm LR (I haven't had any blood work done, just going on symptoms but I have the big ones) and I think I need this for my health overall. I am looking forward to this phase passing though.

          Comment


          • The key with leptin is regaining your own natural sensitivity to allow it to control the other hormones in the body. The only people who really seem to need synthetic leptin are those who seriously damaged their hypothalamus. In SG reward series Inthewoo made some comments that made me realize she was in the Amgen trials and she was one of the people who needed leptin. Most people dont need to take leptin. They just need to learn how to regain its sensitivity. With leptin it is most critical to focus in on timing of when you eat and how meals are spaced and their is no snacking. The secondary importance is the fuel........with regards to the fuel it must be low carb and you must retrain your brain reset the satiety signals with high protein and fat breakfast. Think of the reset as you would when your computer needs repair. You wipe it clean and you put in new drivers or software. They real key is making sure your really leptin resistant. If youre not you just need to eat a paleo diet using leptin principles. You then can add in IFing and go from there. The protocol is easy to do and you will know when youre hitting your stride because their are many symptoms to follow. Some people will have different schedules because their liver or muscles maybe in worse shape than they knew. Horsewoman is one of those in this thread. My ambient awareness of her based upon her posting leads me to believe she is either AR or has a seriously LR liver. Anyone who can go long with out eating and carbs has issues that need to be solved. Im sad that in the UK there are not too many options for her but doing this on her own but hopefully she remains persistent with this because if she does it will get better.

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            • Originally posted by MamaGrok View Post
              Granted my brain hasn't been working well lately, but my reading of that was that taking synthetic leptin supplements wasn't showing itself to be "the answer" for most people, similar to how synthetic hormones haven't been the answer for post-menopausal HRT or thyroid patients, etc. But my guess is that natural leptin supplementation, if it can be developed, or dietary changes, will be the best answer - as in those same other hormonal cases. Dunno if I'm right!
              That's how I read it.
              Georgette

              Comment


              • Originally posted by DigitalSurgeon View Post
                anxiety comes from liver leptin resistance. That is Leptin Part deux. 60% of your serotonin is locked into the gut. Doing a leptin reset effects your gut and the enterochromaffin cells where serotonin lives. The other 40% is in pineal.......for sleep. Quitting that soon is not a good option.
                Originally posted by wylde_child View Post
                So are you saying that this is just a stage in the reset and that I should hang in there and that this too shall pass?
                I'd like to know more about this as well. There are multiple folks who have depression related symptoms when going lower carb--DigitalSurgeon, are you saying this will clear up during the leptin reset (within the 6-8 weeks)? Can you explain anything about this a little more (the serotonin being locked in the gut?) Folks, if you've read about this on Dr.K's blog (or somewhere else) feel free to share a link--don't want to bug the Doc w/ all these questions if he's already answered them elsewhere.

                I recall cillakat having a terrible transition when moving toward a VLC diet. She mentioned 8 weeks of hell and sleeplessness, and then suddenly it all clicked and she felt amazing. (Cillakat also dealt with depression and other issues....) I wonder if that was really a leptin reset for her?...
                My Before/After Pics
                Are you new here? Be sure to check these links FIRST, before reading anything on the forum! Succeed & PB 101

                "I am a work in progress." -Ani DiFranco

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                • Originally posted by DigitalSurgeon View Post
                  Horsewoman is one of those in this thread. My ambient awareness of her based upon her posting leads me to believe she is either AR or has a seriously LR liver. Anyone who can go long with out eating and carbs has issues that need to be solved. Im sad that in the UK there are not too many options for her but doing this on her own but hopefully she remains persistent with this because if she does it will get better.
                  Oh you can certain I will remain persistent lol.

                  I can go 6-7 hrs without eating on low carb, no problem. I don't need carbs for energy, only for the serotonin-raising effect due to their effect on the relative levels of tryptophan and other AAs in the blood. Is that related to AR or LR? I had been assuming it was a separate issue relating to a tendency to low serotonin (both my parents have had depression as well). Is it actually part of the same story?

                  I'm pretty sure I have at least some degree of AR considering everything my body has been through over the last 15 years. LR liver, I'm not sure, I don't have any problem with fueling my body when I am low carb, I felt good on it and was fine to eat 3 times a day, even waiting until after work to have lunch. It was only over time that my serotonin level dropped (coincided with winter... worst seasonal affective disorder ever). I am pretty sure it is serotonin, since 5-HTP helped a lot etc, it all fits. Other than that I felt great on LC and would never have considered giving it up, it was so liberating to not need to think about when I was next going to eat all the time!

                  Originally posted by FairyRae View Post
                  I'd like to know more about this as well. There are multiple folks who have depression related symptoms when going lower carb--DigitalSurgeon, are you saying this will clear up during the leptin reset (within the 6-8 weeks)? Can you explain anything about this a little more (the serotonin being locked in the gut?) Folks, if you've read about this on Dr.K's blog (or somewhere else) feel free to share a link--don't want to bug the Doc w/ all these questions if he's already answered them elsewhere.
                  Sorry, didn't see there was already a similar question posted.

                  I did well over 6-8 weeks of low carb, 3 meals a day, no snacking, 40+g of protein at breakfast but once the low mood kicked in it only got gradually worse. So I couldn't get too hopefully that the reset would help with that issue. Be nice if it did though!
                  Last edited by Horsewoman; 07-14-2011, 06:24 AM.
                  Gluten intolerance and hypermobility syndrome http://www.cfids.org/pdf/joint-hypermobility-guide.pdf

                  Eat food. Mostly real. Enjoy life.

                  Health, energy, wellbeing, vitality, joy, LIFE! Health At Every Size

                  "Do not ask what the world needs; ask yourself what makes you come alive. And then go and do that, because what the world needs is people who have come alive."
                  Harold Whitman

                  Comment


                  • Yesterday was a bit tough for me. I didn't get enough sleep the night before, and then after eating the normal large breakfast, I had a busy and environmentally stressful morning. I didn't finish lunch until 2 pm, and while I ate much less than usual, I thought I would be ok, since I wasn't even hungry in the first place. I thought to myself, "hey, I'm Leptin Sensitive! Is it time for me to go to 2 meals a day?" Soon that thinking was replaced by wondering when I could start eating dinner. I hung on until dinner, and ate a normal one, with a bit more protein than usual to replace what I didn't get at lunch. Then I found myself wanting more stuff, first grabbing cheese and olives, and then going for some carbs. The final blow was making a cake-in-a-mug with real sugar and flour, and even that didn't really help. OK, new equation: no sleep+overwork+undereating = cake!
                    I can't say it was really anxiety, but more of a pacing, an ill-feeling. When I went to bed, I thought I would just put on some relaxing music. I put on the radio, but it got annoying, so I put on a CD, but it was annoying. Then I pulled out some lavender oil, and hated the way it smelled. Finally I just laid down and said, "You are going to lie here until it kills you. There is nothing you can do. Everything is annoying." Of course, it was too hot, then too cold, and the pillow was lumpy etc. etc. etc.
                    I woke up several hours later and everything was perfectly fine.
                    I know that people like SG are so wrong about the food reward thing. When people are trying to manage their moods by ingesting something, it really doesn't matter what it tastes like. The way he dissed that woman's "anecdote", shame on him.
                    So my question is: is there a typical pattern for people who are trying to get out of liver LR? Is it a one-time hump for most, does it drag out for weeks? Am I back on square one with the reset, or still on day 14?
                    Does regular CW dieting and/or IF have the potential to initiate nighttime eating syndrome in people with LR?

                    Comment


                    • I've thought all along my Leptin signalling is OK, but I wanted to try the big protein breakfast just to change things up a little. Did it for about a week. Holy cow! I was starving all day long. I normally don't eat from 6pm-noon, and when I started eating a big, meaty breakfast it gave me hunger signals like crazy, well into the night. I was jonesing for things I haven't even thought about eating since last summer. Went back to my normal IF schedule and all is fine again. I wonder if that's a sign that my Leptin is well-regulated with 6pm-noon IF's or that I do indeed have Leptin issues.

                      Comment


                      • Does regular CW dieting and/or IF have the potential to initiate nighttime eating syndrome in people with LR?
                        Yes-- I would say that IFing when done in a certain manner can totally initiate nighttime eating in some people. (It has for me at least.) If I've used IF to fast all day long, planning to only eat one meal in the evening, it has typically lead to a nighttime binge. (I don't use it in this manner any more because that obviously doesn't work *for me*. I also have a history of binge eating disorder/bulimia, so there you go!) IF, when used in a more lean gains approach (similar to the leptin reset style of eating) has been more successful *for me*. But again, YMMV.

                        According to books like Julia Ross's _The Diet Cure_, a lot of binge eating issues (which can encompass nighttime eating etc) stem from not eating enough high quality foods during the day (so, eating a bunch of nutritionless junk all day, or not eating at all, etc...) She recommends getting in a specific amount of protein and fat, veggies, carbs, etc in order to prevent binge eating issues. I've found that her recs have really helped me personally (eating 4+ cups of non-starchy veggies a day along w/ around 30+ g protein per meal etc.)

                        Just my thoughts on this!
                        My Before/After Pics
                        Are you new here? Be sure to check these links FIRST, before reading anything on the forum! Succeed & PB 101

                        "I am a work in progress." -Ani DiFranco

                        Comment


                        • Originally posted by FairyRae View Post
                          I'd like to know more about this as well. There are multiple folks who have depression related symptoms when going lower carb--DigitalSurgeon, are you saying this will clear up during the leptin reset (within the 6-8 weeks)? Can you explain anything about this a little more (the serotonin being locked in the gut?) Folks, if you've read about this on Dr.K's blog (or somewhere else) feel free to share a link--don't want to bug the Doc w/ all these questions if he's already answered them elsewhere.

                          I recall cillakat having a terrible transition when moving toward a VLC diet. She mentioned 8 weeks of hell and sleeplessness, and then suddenly it all clicked and she felt amazing. (Cillakat also dealt with depression and other issues....) I wonder if that was really a leptin reset for her?...
                          The first week or two on the protocol, I wouldn't say I was depressed. I would snap a lot at people and have highs and lows. I had maybe one day that I felt depressed with extremely energy levels and Dr. K mentioned to eat a spoonful of coconut oil and instantly I was better. I haven't had those feelings in about 2 weeks. I have more energy now than I've ever had, sleep better and don't get nearly as hungry as I used to. I also had really bad acne in the beginning of this as well. Now everything is cleared up and people have told me I look younger now. I will be continuing this past the 6-8 week plan.
                          Georgette

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                          • Originally posted by geostump View Post
                            The first week or two on the protocol, I wouldn't say I was depressed. I would snap a lot at people and have highs and lows. I had maybe one day that I felt depressed with extremely energy levels and Dr. K mentioned to eat a spoonful of coconut oil and instantly I was better. I haven't had those feelings in about 2 weeks. I have more energy now than I've ever had, sleep better and don't get nearly as hungry as I used to. I also had really bad acne in the beginning of this as well. Now everything is cleared up and people have told me I look younger now. I will be continuing this past the 6-8 week plan.
                            Thinking back to when my neurologist took me off all my bi-polar & migraine meds and sent me to a chiropracter...the first thing he had me do besides adjusting me...was start eating 1-2tbs of coconut oil/day... l no longer do that daily but we cook ALOT in coconut oil... hummmm makes me wonder....
                            The most depraved type of human being is the man without a purpose. ~ Ayn Rand
                            What's your purpose? Mine is Optimal Health.

                            Converted to PB November 2010
                            SW 190lb
                            Leptin Reset Redux (1Sep 2011) SW 170lbs
                            25 Sep 2011 160lbs
                            1 Dec 2011 158lbs!
                            GW ~135lbs
                            5'3"
                            Mother of 2, and wife to a kick ass husband...trying to contain chaos and havoc on a daily basis

                            My Journal: http://www.marksdailyapple.com/forum/thread40609.html

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                            • Georgette, I recall that you were feeling you needed more carbs b/c you were slipping into fatigue without, and Dr. K suggested coconut oil instead ... so that's working well for you?

                              Has anyone else tried it?

                              Does it have to be raw? I use a tablespoon to cook my eggs (and yes, it all gets absorbed), but I don't see any effect on energy levels. I'd be willing to try to gulp it down once just to see, but I really do hate plain coconut oil.

                              Is it just CO, or will any fat do? B/c I'll have 1-2T butter a few times a week just b/c I feel the need for it, but it makes no difference in my energy levels ...
                              5'4" 39yo mother to five sweeties & married to their AMAZING DaddyGrok
                              Current Weight: 175lb__________________________________Goal: 135lb
                              Deadlift: 240lb________________________________________Back Squat: 165lb
                              Bench: 130lb__________________________________________Pre ss: 85lb
                              ***Winning a 20-year war against binge eating disorder***

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                              • ive been having trouble with my sleep. i sleep fine for the first 5 or so hours then i wake up about every hour after that till i get up. this seemed to have started when i began the leptin reset.

                                on top of that i seem to have caught a summer cold. chest congestion, sore throat, coughing, stuffy nose, etc. very weird

                                i asked this before and didnt get an answer, since i am waking up in the middle of the night, is that when i should be eating? it seems my cortisol levels would be highest at that point versus 3 or 4 hours later when i get out of bed
                                Primal Chaos
                                37yo 6'5"
                                6-19-2011 393lbs 60" waist
                                current 338lbs 49" waist
                                goal 240lbs 35" waist

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