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I wouldn't. I don't think we understand the whole fructose story yet. People seem to say that natural occurring fructose is not as bad as the isolated/artificially produced stuff (sugar and HFCS). I'm sure I don't know enough to start condemning natural foods. It bothered me that Dr. Davis had a series of posts recently where he was condemning natural fruits that were high in fructose. I don't think the evidence is there yet for that.
I know I was using fructose as an argument against sweet potatoes recently, but I'm not sure that is really warranted and in that case we were talking about things that should be in our diet anyway. I love onion as much or more then then next guy, but I don't eat as much as I would apples or sweet potatoes so I don't think it is a big concern.
The fructose argument with most health issues is referring to fructose in sucrose, and HFCS. Now, certain fruits do also contain fructose, but, those fruits usually contain a wide array of benefits that outweigh the fructose. Flavonids, phytochemicals, phytonutrients, polyphenols, fiber, ect... None or at-least barely at all of any of that is found in larger sources of fructose.
Watermelons don't contain a lot of fructose anyway. They contain some sugar alcohol, can't remember which.
Anyway our liver can process some fructose. So if we are not getting past that limit it should be fine. Just we should chose things that do not contain a lot of fructose as a percentage, so that we don't eat much. For me that means, avoiding very sweet fruits.
Almost every eatable plant parts contain some amount of fructose. It cannot be avoided without becoming a complete carnivore.
I know onion has a lot of sugar, especially red ones, but I still eat them because they make everything so tasty. Here's a visual representation of how much sugar fruits and veggies contain, don't know what %age of that is fructose though.
per USDA, a 15" x 7.5" melon contains 55 grams of sucrose, 75 of glucose, and 152 of fructose. Add the fructose in the sucrose, and that's about 180 grams of fructose. That's closing in on a half pound.