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  • I noticed the voice thing too last year. Somebody posted about it in the thread about odd/unexpected improvements or such. I though my vocal chords were damaged by severe pharangitis about 15 yrs ago (lost my voice for almost a month, could not sing at all - the notes just weren't there anymore). It is simply amazing how much of our being is effected by diet. I've noticed lately that I can sing lower notes than ever before.

    Comment


    • Kkcarlton - I'm praying for this for you, too!

      Mud Flinger - it was probably me posting it, lol. It's one of my first and most treasured improvements. And now it's taken up another notch! I used to be someone who lost my voice almost every time I got an upper respiratory infection. That hasn't happened in ... several years. I just realized that. What a bonus!!
      5'4" 39yo mother to five sweeties & married to their AMAZING DaddyGrok
      Current Weight: 175lb__________________________________Goal: 135lb
      Deadlift: 240lb________________________________________Back Squat: 165lb
      Bench: 130lb__________________________________________Pre ss: 85lb
      ***Winning a 20-year war against binge eating disorder***

      Comment


      • Week 3, Day 6
        BBT - thermometer's batteries are dead
        144 - 100% bloat. why?
        86 days binge-free


        Leptin Resistance goals:
        - Breakfast w/ 50gm of protein yes
        - Breakfast w/i 30m of rising nooooo - just couldn't get going this morning ,drragged around. took nearly two hours to do my normal morning stuff
        - 5+ hrs between Breakfast and Lunch yes, no lunch
        - 5+ hrs between Lunch and Dinner yes, no lunch
        - finished dinner by 7:30? yes, 6:30
        - no snacking yes
        - 3.5+ hrs between dinner & bedtime yes, at least 4
        - exposure to morning sun yes, no lenses, no socks
        - darkening the house at sunset can't yet b/c of dumb full light classroom I'm in.
        - 100% primal diet no - trace of sugar & soy sauce in jerky
        - <50g carb per day, anti-candida (no sweeteners, starches, or fruit) around 20g from frz-dried pineapple
        - no PUFA's other than fCLO yes
        - teaspoon of coconut oil if I start fading 2T extra with bkfst

        Morning
        D (5000IU) - forgot
        HCl -
        Dig Enz - Considering another brand and/or ox bile and/or bile salts
        Organs, broth, ferments: watermelon rind, raw goat liver, & broth for bkfst,

        Midday
        Mg (700mg) -
        Selenium (200mg) - yes
        ACV -
        OOO -
        Green tea -
        Salt and/or potassium - LOTS in my broth
        Seaweed -
        GFCF? yes

        B - 4 eggs in 3T CO, 5.5ish oz sausage, 1oz goat liver, 1+C heavily salted chicken broth, 1 chunk fermented watermelon rind

        D - sausages, bite of egg, stuck in class and got desperate - whole pkg of organic beef jerky, frz-dried pineapple. Still very hungry but no more food.

        Results
        - energy 3/10. Wanted to curl up ALL DAY.
        - bloating = 4mo in morning. Dressing? I had it last week w/o bloating, though? something from party 2 days ago?
        - skin = still smooth, still some bumps on my arms
        - 9.5hrs. sleepy around 11am. 15m nap around 1:30, stayed sleepy ALL day. short respite after dinner, then more sleepysleepy.
        - brief moment of heartburn in evening. Wheat in the soy sauce in the jerky? Dangit. Didn't think about that.
        Last edited by MamaGrok; 01-22-2012, 10:11 AM.
        5'4" 39yo mother to five sweeties & married to their AMAZING DaddyGrok
        Current Weight: 175lb__________________________________Goal: 135lb
        Deadlift: 240lb________________________________________Back Squat: 165lb
        Bench: 130lb__________________________________________Pre ss: 85lb
        ***Winning a 20-year war against binge eating disorder***

        Comment


        • Originally posted by MamaGrok View Post
          Kkcarlton - I'm praying for this for you, too!
          Thanks.
          Started Atkins:: 1996
          Started Paleo: 2003
          Illness Started: 2008
          Started Leptin Reset: 01.10.2012
          Thighs Starting Size: 54.8 cm
          Thighs Goal Size: 53.5 cm
          My Journal: http://www.marksdailyapple.com/forum/thread46986.html

          Comment


          • [Week 3, Day 7
            BBT - thermometer's batteries are dead
            142
            87 days binge-free


            Leptin Resistance goals:
            - Breakfast w/ 50gm of protein yes
            - Breakfast w/i 30m of rising I think so
            - 5+ hrs between Breakfast and Lunch yes, no lunch
            - 5+ hrs between Lunch and Dinner yes, no lunch
            - finished dinner by 7:30? no, 8:30?
            - no snacking well, I called it "a really long dinner."
            - 3.5+ hrs between dinner & bedtime yes, 3.5
            - exposure to morning sun no - overcast & groggy
            - darkening the house at sunset somewhat
            - 100% primal diet no - trace of canola oil in veggies
            - <50g carb per day, anti-candida (no sweeteners, starches, or fruit) yes, <20g
            - no PUFA's other than fCLO dat canola oil
            - teaspoon of coconut oil if I start fading 2T extra with bkfst

            Morning
            D (5000IU) - forgot
            HCl -
            Dig Enz - Considering another brand and/or ox bile and/or bile salts
            Organs, broth, ferments: watermelon rind, raw goat liver, & broth

            Midday
            Mg (700mg) -
            Selenium (200mg) - think I forgot
            ACV -
            OOO -
            Green tea -
            Salt and/or potassium -
            Seaweed -
            GFCF? yes, unless accidental crumb of cheese

            B - 4 eggs in 3T CO, 5.5ish oz sausage, 1oz goat liver, 1C chicken broth

            D - 1 chunk ferm rind, bits of dried veggies, bit of ham steak, 9g carbs worth of pineapple, bite of sweet potato, shrimp, salad, kale, green beans, lamb. quite full.

            Results
            - energy 4/10
            - bloating = 3mo in morning.
            - skin = smoother yet!
            - 10hrs in bed for ~8hrs sleep?
            - definitely was hot at night the last two nights. Dh was not. Good sign?

            Big victory day again - went to family b'day party with ALL my lifelong favorites:
            - bread w// a side of chicken (chicken & dumplings)
            - bread w/ a side of chicken (chicken club ring)
            - bread w/ a side of sweet potatoes (sw tater casserole)
            - bread w/ a side of cheese (mac & cheese)
            - bread w/ a side of bananas (banana pudding)
            - bread. B/c you can't have a meal w/o bread!

            And I went on a full (bkfst) tummy and had absolutely no trouble avoiding all of it. Didn't eat a bite. Didn't care. Kept looking for a craving, but didn't find one. This is stuff I ABSOLUTELY could not have escaped without a major binge (likely followed by another binge at night and the next three days) even just six months ago.

            Wow wow wow. Didn't care. Didn't care at all!
            Last edited by MamaGrok; 01-22-2012, 10:19 AM.
            5'4" 39yo mother to five sweeties & married to their AMAZING DaddyGrok
            Current Weight: 175lb__________________________________Goal: 135lb
            Deadlift: 240lb________________________________________Back Squat: 165lb
            Bench: 130lb__________________________________________Pre ss: 85lb
            ***Winning a 20-year war against binge eating disorder***

            Comment


            • Wow, it seems like you've reached another level of success! I just look at that kind of food like poison now, and allow myself whatever I want when I get home. I had a B-day party today (kids-4yr old) and also ate nothing. It's just not worth it. The food is not that great and I am worth so much more than a silly party treat. Glad you have come to that conclusion too!

              Comment


              • ANd did it again tonight at a second party! Usually a two-party day is a recipe for disaster even in the last few months. Nothing. I sat right in front of many different desserts, including gluten-free ones, and ate nothing and wanted nothing. (It does help to have a "closing time" for eating at night.)

                I came to the conclusion it wasn't worth it several years ago, but couldn't act on that conclusion until just the last few weeks. Now, I don't have to fight my desires against my knowledge ... they match. Woohoo!
                Last edited by MamaGrok; 01-21-2012, 09:32 PM.
                5'4" 39yo mother to five sweeties & married to their AMAZING DaddyGrok
                Current Weight: 175lb__________________________________Goal: 135lb
                Deadlift: 240lb________________________________________Back Squat: 165lb
                Bench: 130lb__________________________________________Pre ss: 85lb
                ***Winning a 20-year war against binge eating disorder***

                Comment


                • Week 4, Day 1
                  BBT - thermometer's batteries are dead
                  <142
                  88 days binge-free


                  Leptin Resistance goals:
                  - Breakfast w/ 50gm of protein yes
                  - Breakfast w/i 30m of rising no - sick baby on lap as soon as I got up, couldn't make bkfst for over 2 hrs
                  - 5+ hrs between Breakfast and Lunch yes, no lunch
                  - 5+ hrs between Lunch and Dinner yes, no lunch
                  - finished dinner by 7:30?no, 8
                  - no snacking yes
                  - 3.5+ hrs between dinner & bedtime yes
                  - exposure to morning sun no - overcast, baby in lap and couldn't get out, woke at almost 11am anyway.
                  - darkening the house at sunset yes
                  - 100% primal diet except trace of canola
                  - <50g carb per day, anti-candida (no sweeteners, starches, or fruit) way less
                  - no PUFA's other than fCLO trace of canola
                  - teaspoon of coconut oil if I start fading 2T extra with bkfst

                  Morning
                  D (5000IU) - 20,000IU to make up
                  HCl -
                  Dig Enz - Considering another brand and/or ox bile and/or bile salts
                  Organs, broth, ferments: raw goat liver & broth for bkfst,

                  Midday
                  Mg (700mg) -
                  Selenium (200mg) - yes
                  ACV -
                  OOO -
                  Green tea - two C before bed
                  Salt and/or potassium -
                  Seaweed - 1/2 tsp seagreens
                  GFCF? yes

                  B - 4 eggs in 3T CO, 5.5ish oz sausage, 1oz goat liver, 1C chicken broth, bits of veggies fried in canola oil. :P

                  D - some sausage, eggs, & ham steak. Very still hungry

                  Results
                  - energy ?/10
                  - bloating = 3.5mo in morning. 4 & painful at bedtime. Too much liquid?
                  - skin = quite smooth
                  - 9hrs
                  - warm again last night
                  - waist, hip, glut measurements all down from 6 days ago.
                  - belly quite sore last night and this morning in stomach and/or small intestine area - canola? handling cookies?
                  Last edited by MamaGrok; 01-23-2012, 07:26 AM.
                  5'4" 39yo mother to five sweeties & married to their AMAZING DaddyGrok
                  Current Weight: 175lb__________________________________Goal: 135lb
                  Deadlift: 240lb________________________________________Back Squat: 165lb
                  Bench: 130lb__________________________________________Pre ss: 85lb
                  ***Winning a 20-year war against binge eating disorder***

                  Comment


                  • LAB RESULTS! I don't have them all in yet, but here are the ones I do.

                    First number column is the result from 3/2011 - 3 months before my first LR attempt.
                    Second number column is from 1/2012 - after 6 weeks of weekend binges followed by 6 months of trying to stick to the LR reset and finally doing it, with 3 weeks of 100% no grain, sugar, or dairy, and negligible nightshades, at the end.
                    Third number column is the lab range.

                    Red = outside the range, orange = edge of range, lime (yellow doesn't work here!) = lower (or higher) than we probably want.

                    The notes are ones I made when researching the various lab results. They may or may not be right.

                    CBC
                    WBC 5.5 5.4 (4-10.5) (high would indicate infection)
                    RBC 4.44 4.75 (3.8-5.1 or 4.2-5.7, depending on who you ask) (low would indicate anemia)
                    Hemoglobin 13.1 13.8 (11.5-15 or 13.2-16.9, depending on who you ask) (Low can indicate anemia)
                    Hematocrit 40.5% 43.3 (34-44 or 38.5-49, depending on who you ask) (low can indicate anemia)
                    MCV 91 91 (80-98) (low or high can mean anemia)
                    MCH 29.5 29.1 (27-34) (can indicate anemia if hemog & hemat are also low)
                    MCHC 32.3 31.9 (32-36) (can indicate small RBC anemia if MCH is also low)
                    RDW 14.4% 12.6 (11.7-15) (can point toward which type of anemia; high can indicate Fe-deficiency instead of B12 alone)
                    Platelets 217 256(140-415) (ability to clot)
                    Neutrophils 39% 50 (40-74) (low can indicate aplastic & B12 anemias, lupus, etc.)
                    Neutrophils absolute 2.1 2.7 (1.8-7.8 or 2.5-7.5 depending on who you ask)
                    Lymphocytes 50%41 (14-46) (high indicates infections)
                    Lymphocytes absolute 2.8 2.2 (.7-4.5)
                    Monocytes 8% 6 (4-13) (low = higher risk for infection)
                    Monocytes absolute .4 .3 (.1-1.0)
                    Eos 2% 2 (0-7)
                    Eos Absolute .1 .1 (0-.4)
                    Basos 1% 1 (0-3)
                    Basos Absolute .1 .1 (0-.2)
                    Immature Granulocytes 0% 0 (0-1)
                    Immature Grans Absolute 0 0 (0-.1) (higher can indicate leukemia)

                    Blood Sugar
                    Glucose 83 (65-99)
                    Ha1C 4.9% (4.8-5.6) (coming off of binges every few months)
                    Insulin 4.8 (0-24.9) (Dr. Kruse says <4?)

                    Liver/Kidney
                    BUN 13 (6-20)
                    Creatinine .72 (.57-1)
                    eGFR 109 (>59) (early kidney disease indicator)
                    BUN/Crea ratio 18 (8-20) (elevated okay if BUN is fine, but can indicate gastro bleeding)
                    Na 144 (135-145)
                    K 4.2 (3.5-5.2)
                    Cl 108 (97-108)
                    CO2 27 (20-32)
                    Ca 9.2 (8.7-10.2)
                    Protein 6.7 (6-8.5)
                    Albumin 4.2 (3.5-5.5)
                    Globulin 2.5 (1.5-4.5)
                    A/G Ratio 1.7 (1.1-2.5)
                    Bilirubin .3 (0-1.2)
                    ALP 78 (25-150)
                    AST 15 (0-40)
                    ALT 12 (0-40)

                    Urinalysis
                    Specific Gravity 1.029 (1.005-1.03) (high can indicate high glucose or contamination) (interesting; I often think I have spillover despite b.g. readings only around 130-140 ... but my urine glucose reading was negative!)
                    pH 6.5 (5-7.5)
                    Color Yellow (Yellow)
                    Appearance Clear (Clear)
                    WBC Esterase Neg (Neg) (Neg = infection highly unlikely w/o other UTI symptoms)
                    Protein, Glucose, Ketones, Occult Blood, Bilirubin all Neg (Neg)
                    Urobilinogen .2 (0-1.9) (is low a problem? wiki implies yes)
                    Nitrite; Urine Pos (Neg) (Pos indicates bacteria may be present in significant numbers. What does positive nitrite but negative esterase mean, esp. when microscope finds no bacteria?)
                    Microscopic examination of WBC Esterase, RBC, Epithelial, & Bacteria are all exactly as the ranges say they should be.
                    Mucus Threads Present (Not Estab.)

                    Lipids
                    Total Cholesterol 277 (100-199)
                    Triglycerides 78 (0-149)
                    HDL 80 (>39)
                    VLDL 16 (
                    LDL Calc. 181 (0-99) (163 by Iranian formula, lugnuts!)
                    LDL/HDL Ratio 2.3 (<3.3)
                    Total/HDL Ratio 3.46
                    Trig/HDL .975

                    Thyroid - I don't really know how to interpret these numbers
                    Free T4 1.17 (.828-1.77)
                    Free T3 2.5 (2-4.4)
                    TSH 1.43 (.45-4.5)
                    B12 790 1391 (211-946) (Dr. Kruse says >1000?)
                    Ferritin 142 190 (13-150)

                    Vitamin D - 23 at the time of the 3/11 test, 63 six months later.

                    TIBC xxx 286 (250-450)
                    UIBC xxx 209 (150-375)
                    Iron, serum xx 77 (35-155)
                    Iron, Saturation xx 27% (15-55)
                    Reticulocyte Count xx .6 (.5-2.8) (low is good?)

                    Alright, I don't like this format. I'm going to do a screenshot from the spreadsheet so everything's in tables next...
                    5'4" 39yo mother to five sweeties & married to their AMAZING DaddyGrok
                    Current Weight: 175lb__________________________________Goal: 135lb
                    Deadlift: 240lb________________________________________Back Squat: 165lb
                    Bench: 130lb__________________________________________Pre ss: 85lb
                    ***Winning a 20-year war against binge eating disorder***

                    Comment


                    • Okay more labs! This is all of the ones I have so far. I'm expecting all the rest to come some time this week, but am trying to wrap my brain around the ones in so far. Welcoming feedback, come one and all!

                      So far, I'm surprised that B12 is exceptional & there are no pathogenic bacteria or yeast problems, can't understand how my cortisol is as "high" as it is given how I feel, perplexed how I can have crazy high ferritin & B12 + fine hemoglobin & hematocrit with low other iron indicators, and a few other bizarre things. Wasn't expecting gluten antibodies or a positive ANA. Testosterones & Estradiol are clearly low and I have no idea what to do about it, but I'll ask more after getting in the rest of the steroid panel. Looking forward to thyroid results!

                      Day 5 of cycle (day 4 for jansz )




                      Last edited by MamaGrok; 01-22-2012, 06:09 PM.
                      5'4" 39yo mother to five sweeties & married to their AMAZING DaddyGrok
                      Current Weight: 175lb__________________________________Goal: 135lb
                      Deadlift: 240lb________________________________________Back Squat: 165lb
                      Bench: 130lb__________________________________________Pre ss: 85lb
                      ***Winning a 20-year war against binge eating disorder***

                      Comment


                      • helllooo, major learning point today. Dr. Kruse o nmy labs:

                        your labs indicate you gut is so leaky you are close to to developing autoimmunity. The facts that B12 is up is great......but you need to consider IV glutathione treatment now to really help with your diet. You must remain strict on your diet as you have done. I think the key is going hard after your gut. it is where your battle is really at.

                        Glutathione must be given via IV. It's digested very rapidly when given orally. Intramuscular injections are somewhat effective, but it's minimal. Also included in our treatment is the amino acid N-Acetyl Cysteine (NAC). The use of milk thistle has been shown to cause retention of glutathione, so it is part of our program. Glutathione therapy

                        Important reading: IV Glutathione Therapy

                        Need to search MDA, leptin threads, & jackkruse.com on glutathione, NAC, ANA, antigliadin, MSH, and more!

                        Dr. K's Leaky Gut Rx says 600mg 2x/day NAC + 1000mg Vit C daily will make glutathione.
                        5'4" 39yo mother to five sweeties & married to their AMAZING DaddyGrok
                        Current Weight: 175lb__________________________________Goal: 135lb
                        Deadlift: 240lb________________________________________Back Squat: 165lb
                        Bench: 130lb__________________________________________Pre ss: 85lb
                        ***Winning a 20-year war against binge eating disorder***

                        Comment


                        • Week 4, Day 2
                          BBT - thermometer's batteries are dead
                          141.75!!
                          89 days binge-free


                          Leptin Resistance goals:
                          - Breakfast w/ 50gm of protein yes
                          - Breakfast w/i 30m of rising yes - ignored crying sick toddler to get it in on time
                          - 5+ hrs between Breakfast and Lunch yes, no lunch
                          - 5+ hrs between Lunch and Dinner yes, no lunch
                          - finished dinner by 7:30? no, 8
                          - no snacking yes. was snacky around 3:30-5, though.
                          - 3.5+ hrs between dinner & bedtime
                          - exposure to morning sun no - thickly overcast
                          - darkening the house at sunset yes
                          - 100% primal diet probably not
                          - <50g carb per day, anti-candida (no sweeteners, starches, or fruit) yes
                          - no PUFA's other than fCLO don't know yet, depends on the pie
                          - teaspoon of coconut oil if I start fading 2T extra with bkfst

                          Morning
                          D (5000IU) - forgot
                          HCl -
                          Dig Enz - Considering another brand and/or ox bile and/or bile salts
                          Organs, broth, ferments: raw goat liver & broth for bkfst, broth & kidney for dinner

                          Midday
                          Mg (700mg) -
                          Selenium (200mg) - yes
                          ACV -
                          OOO -
                          Green tea - two cups
                          Salt and/or potassium - tsp css in broth
                          Seaweed -
                          GFCF? yes (unless in cupcakes)

                          B - 4 eggs in 3T CO, 5 oz sausage, 1oz goat liver, 1C heavily salted chicken broth

                          D - one bite gluten-free (think dairy-free, too) cupcake, ~1/3 slice gfcf pecan pie, steak & kidney stew (carrots, shrooms, think I avoided the peppers), ham steak, sausage.

                          Results
                          - energy 4-6/10
                          - bloating = 3-4mo in morning. ? Stomach was very uncomfortable to the touch all last night. 5+mo pg looking before bed. HOLY CUPCAKE!
                          - skin = quite smooth
                          - 9.5 miserable hours. First 3 I was mostly awake, able to sleep some. Then felt quite good and not sleepy and was wondering if I was going to wake up refreshed & LS. Then DD would not go back to sleep for more than a few minutes at a time and I hardly got any sleep over the next several hours. :P
                          - warm before bed, very warm all night. 68 degrees and I wanted no sheets from 11pm till closer to 6am. Weird! Good sign, I think.
                          - Felt fat & water melting away during my sleep. 142 at night, expected to be 140.5 this morning, but same as yesterday instead. What is that pain & distension in my belly? Very sleepy this morning. Very thirsty. Kept drinking, kept thirsting. fast loose elimination midday followed by less bloating & increased energy & alertness. Ate the bite of sweets, got dizzy, woozy, and sleepy very quickly. No bloating (yet). Is it the sugar? Could be brown rice syrup. Processed oil? I doubt it. Waiting for inggredients list.
                          - taught PSR kids some music today. Last time I did this was the worst yet. I was DREADFULLY tired, could hardly keep myself going. Today, I almost enjoyed it, lol. Definitely had energy, was jumping around again, smiling, feeling good. (till the sweets woozified me). Yay!
                          - Took my skinny jeans off without buttoning. Definitely yay. (still can't fit in the next ones yet)
                          Last edited by MamaGrok; 01-24-2012, 07:22 AM.
                          5'4" 39yo mother to five sweeties & married to their AMAZING DaddyGrok
                          Current Weight: 175lb__________________________________Goal: 135lb
                          Deadlift: 240lb________________________________________Back Squat: 165lb
                          Bench: 130lb__________________________________________Pre ss: 85lb
                          ***Winning a 20-year war against binge eating disorder***

                          Comment


                          • Originally posted by hazyjane View Post
                            Transdermal glutathione is part of my Hashi's protocol: Apex Energetics OxiCell Cream K-22 1.6 oz . It bypasses the liver and is easy to get into the system. Dr. Kharrazian formulated it for his patients. He also created a glutathione recycling formula to be used with it:
                            Apex Energetics GLUTATHIONE RECYCLER K-57 90 caps
                            Dr. K: getting glutathione into cells is very difficult. You usually have to use lipid immersions and they are quite expensive. The IV dosing can really help people with leaky guts who just fall apart of struggle to get back on their feet.

                            I usually send patients to natropaths who are experienced in it. I would tell you to go the the main site for function medicine and do a search there based upon geography to find a provider. Medical doctors are clueless about this. Some compounding pharmacies do offer these services.


                            best source of glutamine - broth.

                            Dietary glutathione is found in high amounts in fresh, uncooked meats and in moderate amounts in dairy products and eggs. These foods are high in whey protein containing alpha-lactalbumin which is rich in sulfur-containing amino acids. These products optimize the use of glutathione within the body. Cooking and prolonged storage reduces glutathione content of these foods. However, the glutathione content of these foods is high enough that consuming these products after cooking and processing provides the body with sufficient sources of glutathione.

                            Read more: Food Sources Of Glutathione | LIVESTRONG.COM

                            Selenium is an important co-factor for the enzyme form of glutathione. Selenium is necessary for formation of glutathione containing enzymes.


                            From Digital Surgeon:

                            The Hashimoto's thing......it makes up 95% of all hypothyroid human cases today and it treated by medicine with CW. Most who have it have leaky guts and low levels of intracellular glutathione. Glutathione is a very important antioxidant that plays an important role in maintaining the correct oxidation-reduction potential inside cells. It scavenges oxidising free radicals, detoxifies heavy metals, pesticides, tylenol and leukotrienes. It stores and transports amino acids, regulates the cell cycle, protein synthesis and gene expression, and protects thyroid cells from self-generated hydrogen peroxide. Glutathione is quite important for patients with Hashimoto's. Glutathione protects the body in an extraordinary number of ways, but the fact that it protects the thyroid against hydrogen peroxide is particularly significant for the thyroid. In untreated Hashimoto's, the body's levels of T4 (thyroxine) begin to fall, and TSH (thyroid stimulating hormone) levels generally start to climb. In order to stimulate the thyroid to make more T4, the TSH activates the thyroid cells to make hydrogen peroxide. If the TSH levels remain high, the thyroid cells continue to produce more and more hydrogen peroxide, and this can lead to increased inflammation, scarring, and ultimately the destruction of thyroid cells. If the hydrogen peroxide manages to gain entry to the cell, the damage becomes far worse.

                            Hydrogen peroxide is thought to play a significant role in the development and progression of Hashimoto's disease, despite the fact that the thyroid gland actually requires hydrogen peroxide for thyroid hormone formation. Hydrogen peroxide is normally produced during the oxidation of the iodine ions. It is an essential part of the thyroid function. But the critical factor is the protection of the thyroid cells (glutathione level), and the place in which the iodine ions are oxidized. If oxidation occurs inside the cells, the hydrogen peroxide is produced inside the cells, and the cells sustain damage.

                            A study found that if hydrogen peroxide is allowed to enter thyroid cells, it attacks and cleaves thyroglobulin (protein within the thyroid), producing fragments that are able to diffuse into other cells – and these fragments were recognized by autoantibodies taken from people with Hashimoto's disease. This suggests that hydrogen peroxide entry into thyroid cells may actually be the cause of Hashimoto's disease!!!! SO if you have Hashimoto's your glutathione levels maybe a proxy of how bad your disease really is. It can be a measure of really how leaky your gut is too.

                            The predominant infiltrating cells in autoimmune diseases such as Hashimoto's thyroiditis are phagocytic macrophages, neutrophils and various T-cells; the macrophages and neutrophils damage the tissues by releasing inflammatory cytokines and proteins, including hydrogen peroxide making things worse because this further depletes glutathione inside the cells. This is complicated by co-morbid B12 and folate deficiencies in the diet because of the leaky gut. Glutathione requires both to be on hand to work well!

                            The body's stores of glutathione can become depleted through any stressor. For example, alcoholism, HIV infection, cirrhosis, diabetes, surgical trauma, fasting, environmental toxins, overuse of acetaminophen, chronic stress, inadequate diet, elevated adrenaline release, extensive strenuous exercise, or infection. It is also associated with cigarette smoking, as smoking increases the rate at which the body uses glutathione.

                            Glutathione is not easily absorbed through oral supplementation, but is synthesized in the body from amino acids, and body levels can be increased through oral administration of glutathione precursors such as N-acetylcysteine (NAC), S-adenosyl-L-methionine (SAMe) and L-gluatmine. Getting it into cells is even tougher and requires IV infusions using lipid soluble mediums. For serious autoimmune diseases it is often a great treatment. Oral administration of NAC of doses up to 8,000 mg/day was not found to cause clinically significant adverse reactions, although doses of 600mg/day were enough to significantly improve symptoms of chronic lung disease like COPD. I have used over 3000 mgs a day when my HS-CRP was around 3.0. When I have falls in Vitamin D levels I also reach for NAC or sometimes WHEY protein. Whey also breaks down into glutathione and reduces inflammation. This is why Whey use can augment weight loss in people with high CRP's

                            Intake of NAC does increase zinc loss through urine, so zinc supplementation would be advisable for anyone supplementing NAC over an extended period. This can deplete your sex steroid hormones if you do not eat a lot of foods with zinc. Me personally when I take a ton I always make my oysters rockerfeller recipe.

                            Glutathione can also be up-regulated by vitamins C and E, and alpha lipoic acid, PQQ, spinach, offal, yeast extract, and broccoli. N-acetylcysteine is considered to be the most effective, fastest route to raising levels of glutathione. It also increases levels of glutathione only when there is an actual need, and it seems to concentrate only in tissues where glutathione is required. This need corresponds to high MMP9 levels in cells.

                            The fact that NAC is able to restore glutathione levels and thereby protect the thyroid is particularly interesting given its ability to crack open bacteria such as chlamydia pneumonia, which hide inside the body's own cells during one part of their life cycle, using the host cell's machinery to replicate. Chlamydia pneumoniae has been implicated in autoimmune diseases such as multiple sclerosis, and N-acetylcysteine is considered an important part of treatment. I do not consider these diseases as part of AI's. I consider finding titers of these in patients to be patho-mneumonic that glutathione levels are very very low in these people.



                            Beef Liver Pâté with Shallots and Bacon (A Tasty Nutrient-Dense Snack!) beef liver pate

                            maile: your labs indicate you gut is so leaky you are close to to developing autoimmunity. The facts that B12 is up is great......but you need to consider IV glutathione treatment now to really help with your diet. You must remain strict on your diet as you have done. I think the key is going hard after your gut. it is where your battle is really at.

                            (maybe I should consider being really fastidious about cross-contamination and handling, and see if that helps further?)



                            Jill: Is glutathione therapy used to treat any other conditions besides PD?

                            Dr. Perlmutter: It's been very effective in treating irritable bowel syndrome, and I don't have a clue why. We use it to treat all neurodegenerative symptoms, but it is also part of our treatment for fibromyalgia and chronic fatigue syndrome.

                            Jill: Do patients need to go to your health center in Florida to receive this treatment?

                            Dr. Perlmutter: No. I have an instructional videotape available on my website and I receive six or eight phone calls every day from doctors around the country. I'm happy to work with them. It's something any physician can do in his or her office and ultimately, the patients or their families can learn to do it at home.
                            http://www.drhoffman.com/page.cfm/197
                            Last edited by MamaGrok; 01-23-2012, 01:39 PM.
                            5'4" 39yo mother to five sweeties & married to their AMAZING DaddyGrok
                            Current Weight: 175lb__________________________________Goal: 135lb
                            Deadlift: 240lb________________________________________Back Squat: 165lb
                            Bench: 130lb__________________________________________Pre ss: 85lb
                            ***Winning a 20-year war against binge eating disorder***

                            Comment


                            • N-Acetyl-L-Cysteine
                              600 mg, 60 capsules
                              Item Catalog Number: 00215
                              N-acetyl-L-Cysteine, 600 mg 60 capsules

                              $9.11

                              cortisol low
                              Estradiol sensitive=19(9-175)
                              Testosterone Total=39 Females: 18-69 years: 2-45 ng/dL
                              Testosterone, Free=0.26(0.1-0.85)
                              You have high-ish testosterone and rather low freeT----->high SHBG


                              N-Acetyl-L-Cysteine
                              600 mg,250 capsules
                              Now Foods, NAC, 600 mg, 250 Vcaps - iHerb.com

                              $22.08

                              With the nice addition of Molybdenum witch is good for leaky gut.
                              Molybdenum



                              kruse: B12 and folate are required for glutathione to work......and Ironically they are required for the Th1 and 2 proteins that are critical in immune activation. This is a key pathway in Hashimotos and many other autoimmune diseases.

                              cascade: Remember, the LDL is the cornerstone for all steroid hormones...You are seeing a correction on your Estradiol, and Progesterone - has you T come down as well? right now when you look at your DHEA-S - its in the low range; you're probably experiencing some pregnelone steal; so your LDL isn't being converted properly to the steroid hormones. How's the cortisol? If your cortisol is good, I would think that as you fix how your body clears the RT3, and begins to use T3 - you'll begin to see your body use up the LDL to make the steroid hormones... it might also slow production b/c you're your body might actually be in the process of trying to reach homeostasis as you fix the RT3; however, remember as we age - they don't fill up as much, which is why bio-identical hormone replacement is something that should be looked into.

                              kruse to jansz on me: bhigh SHBG equals bad bod comp or more fat to lean muscle......of a problem of estrogen dominance......or both.

                              kruse: I think many might not know excessive exercise increases gut permeability across the board. So in the leaky gut Rx we have the same recommendation for exercise. Small amounts are OK but nothing aggressive. I really like just heavy lifting during your home based cures.

                              Colostrum seems to help leaky guts not only in infants but in adults with leaky guts. This is why so many body builders use colostrum when they are overtraining. Here is a study linking the good effects of colostrum.

                              ingentaconnect Bovine Colostrum Supplementation and Exercise Performance: Potent...

                              This is why those with leaky guts should consider backing off exercise just like I recommend in the Leptin Rx for the same reason. It drives up IL-6 while increasing the cortisol to DHEA level and will hurt metabolism and sleep.


                              glam: I think many might not know excessive exercise increases gut permeability across the board. So in the leaky gut Rx we have the same recommendation for exercise. Small amounts are OK but nothing aggressive. I really like just heavy lifting during your home based cures.

                              Colostrum seems to help leaky guts not only in infants but in adults with leaky guts. This is why so many body builders use colostrum when they are overtraining. Here is a study linking the good effects of colostrum.

                              ingentaconnect Bovine Colostrum Supplementation and Exercise Performance: Potent...

                              This is why those with leaky guts should consider backing off exercise just like I recommend in the Leptin Rx for the same reason. It drives up IL-6 while increasing the cortisol to DHEA level and will hurt metabolism and sleep.

                              MSM works on Skin because of the Sulfur cross links it makes in skin.


                              testosteronecream.biz, lol: The androgen insufficient human female was defined as:

                              Diminished sense of well-being, dysphoric mood and/or blunted motivation
                              Persistent, unexplained fatigue
                              Sexual function changes, including lowered libido, sexual receptivity and pleasure
                              Potential bone loss, decreased muscular strength, changes in cognition / changes in memory



                              kruse to me: it tells me you're doing more right than wrong if B12 and folate is solid.......IV glutathione maybe your kill shot for the gut. If you choose not to do it.......just continue to eat well and protect your gut. The gut is your issue.
                              Last edited by MamaGrok; 01-23-2012, 07:19 PM.
                              5'4" 39yo mother to five sweeties & married to their AMAZING DaddyGrok
                              Current Weight: 175lb__________________________________Goal: 135lb
                              Deadlift: 240lb________________________________________Back Squat: 165lb
                              Bench: 130lb__________________________________________Pre ss: 85lb
                              ***Winning a 20-year war against binge eating disorder***

                              Comment


                              • Took my skinny jeans off today without unbuttoning. Never been able to do that with these before. Booyah!
                                5'4" 39yo mother to five sweeties & married to their AMAZING DaddyGrok
                                Current Weight: 175lb__________________________________Goal: 135lb
                                Deadlift: 240lb________________________________________Back Squat: 165lb
                                Bench: 130lb__________________________________________Pre ss: 85lb
                                ***Winning a 20-year war against binge eating disorder***

                                Comment

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