I am also very flat footed. Been that way since I was a kid. My parents always had me in orthotics with "arch support" etc. In my twenties, I always made sure to have the best motion control shoe available. Regardless, I always had ankle or knee pain, and could only run 5 miles or less and usually had to give two to three days between runs to recover. I started running in Vibrams and other minimalist shoes last August. The knee pain was gone immediately for the first time in my life. That was directly attributed to no more heel striking. Makes sense, much less impact. Gradually my ankle and foot pain has gone also. I attribute that to allowing me feet to do what the do best, support. The muscles got stronger and the pain became less. I'm a nurse also, so I stand all day for 12 hour shifts 3-4 times a week. No pain from that anymore either. Along with Primal eating, minimalist footwear is one of the best things I have done for myself. I can run 5 days in a row if I want to now. Like people have already mentioned though. You have to stop heel striking when running. Watch some videos of pose or chi running on youtube, and imitate those styles. Practice at it. The results will be very much worth the effort.
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