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Let me introduce myself. My name is Mark Sisson. I’m 63 years young. I live and work in Malibu, California. In a past life I was a professional marathoner and triathlete. Now my life goal is to help 100 million people get healthy. I started this blog in 2006 to empower people to take full responsibility for their own health and enjoyment of life by investigating, discussing, and critically rethinking everything we’ve assumed to be true about health and wellness...

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January 18, 2008

Where Have All the Studies Gone?

By Mark Sisson
3 Comments

With all the attention on Vytorin and Xetia’s unfortunate research results this week, the media is (for the moment anyway) hot on the trail of Big Pharma’s indiscretions. The latest dirt highlights the industry’s so-called “file drawer” treatment of negative drug research findings. The New England Journal of Medicine report focuses on the publication (or lack thereof) of antidepressant drug studies, but it’s clear these selective practices are commonplace.

Take a look:

Nearly a third of antidepressant drug studies are never published in the medical literature and nearly all happen to show that the drug being tested did not work, researchers reported on Wednesday. In some of the studies that are published, unfavorable results have been recast to make the medicine appear more effective than it really is, said the research team led by Erick Turner of the Oregon Health & Science University. Even if not deliberate, this can be bad news for patients, they wrote in their report, published in the New England Journal of Medicine. ‘Selective publication can lead doctors to make inappropriate prescribing decisions that may not be in the best interest of their patients and, thus, the public health,’ they wrote.

via Yahoo News

As cynical as I am about Big Pharma’s doings, I acknowledge that medical research isn’t always a perfectly clear cut process. Research with humans, in particular, is especially difficult to tightly control, and there are sometimes unknown factors that cloud findings. Researchers can only limit variables they are aware of. Ten years ago, for example, we didn’t know as much about the role of inflammation in heart disease, and researchers wouldn’t have checked for it in targeting or assessing their samples.

This report, however, exposes the insidious side that exists in research, particularly when there’s profit to be had. Industry spokespeople were quick to deflect blame, saying they are “committed” to disclosing results but “negative” outcomes aren’t chosen for publication by medical journals as often as positive results. Others, including a representative from Pfizer, said that all findings are reported on the Internet.

The fact is, I’d bet my bottom dollar that these companies don’t spend a fraction of the time and energy informing doctors of unflattering study results as they do courting them with their latest concoctions. It’s clear where the industry’s “commitment” is.

Last week I brought you news that Big Pharma was spending twice the amount on advertising in the U.S. as it was on research and development. This week’s Vytorin/Xetia outrage highlighted the comparative drug costs: these drugs cost more than three times the amount of their now generic statin predecessors, drugs that (according to the purposefully delayed study results) did the assigned job better than the slick new products. The insane greed boggles the mind.

There are a host of losers in this game – many with huge economic stakes. But the biggest stake of all is the life, the health of patients, patients who can’t get the appropriate care and advice because their doctors are just as blind (although with distinct advantages and, I would argue, much more responsibility). It’s a wretched fix we’re all in.

The industry, the medical community, conventional medical practices and assumptions, government, insurance companies, consumer buy in: where do we begin? Give me your answers, your rants, your reactions.

Bethany L King Flickr Photo (CC)

Further Reading:

Vytorin: Big Blow for Big Pharma

The Almighty Power of the Pill

Pharmalot: Clinical Trials Exaggerate Antidepressant Benefits

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3 Comments on "Where Have All the Studies Gone?"

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Dave C.
8 years 8 months ago

I think the real kicker is that the whole cholestoral hypothesis seems to be crumbling so Big Pharma may be making a bundle on a cure that no one needs!!

Scott Kustes
8 years 8 months ago
The sad truth is that regardless of whether the cure is needed or not, Big Pharma isn’t going to stop until everyone is popping pills daily for the rest of their lives to treat some invented disease (see: Restless Legs Syndrome). The pharma companies did and continue to do some good, but unfortunately it’s balanced by lots of greed – “misinterpreted” studies, unreported negative results, and created diseases – that more than overcome the good done by fixes like insulin for Type I diabetics. Where we begin is with everyone (or at least those that aren’t game for a quick-fix… Read more »
George Street
George Street
4 years 1 month ago

This is a great article, it should definitely be reposted.

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