Comments on: Nature Tops Nurture? Scientists Wrong Again… http://www.marksdailyapple.com/control-gene-expression/ Serving up health and fitness insights (daily, of course) with a side of irreverence. Sat, 21 Nov 2009 16:35:06 -0700 http://wordpress.org/?v=2.8.1 hourly 1 By: The Best of Mark’s Daily Apple: February 2008 | Mark's Daily Apple http://www.marksdailyapple.com/control-gene-expression/#comment-434073 The Best of Mark’s Daily Apple: February 2008 | Mark's Daily Apple Fri, 31 Jul 2009 22:26:41 +0000 http://www.marksdailyapple.com/control-gene-expression/#comment-434073 [...] Nature Tops Nurture? Scientists Wrong Again… – Feb. 8 [...] [...] Nature Tops Nurture? Scientists Wrong Again… – Feb. 8 [...]

]]> By: Alyson http://www.marksdailyapple.com/control-gene-expression/#comment-423155 Alyson Wed, 15 Jul 2009 20:12:15 +0000 http://www.marksdailyapple.com/control-gene-expression/#comment-423155 Ug. I have had many conversations with friends about this subject, and all I have to say is: Please acknowledge that there are some people who do have genetic factors that will cause them to be overweight. Is that true for the majority of Americans? No(We're talking 1 in a couple thousand). However, people who have these problems and the like should not have to listen (again) to how their excess weight is their own fault. Do you blame the cancer patient for losing weight during chemo? No. Don't blame the people with true health issues. (Ok, this is usually the point where I get asked how I can say this, so I will continue with the monologue.) Two years ago I started experiencing extreme weight gain (i.e. 20 lbs in 4 weeks). Needless to say, I freaked out. I was doing light cario, lifting weights, eating only meat and raw vegetables, keeping a food journal, and eventually tracking calories. I went into the doctor and found out (months later) that my body had stopped producing estrogen and was storing fat to compensate. All in all, I gained 55 lbs in 6 months. I am still trying to get back to my normal weight (half way there!). I will never forget the cruel comments that I received from friends and acquaintances and I make an effort to never put anyone else in that position. On a different note: Awesome post on women and weight lifting! As a college age female I am always suprised at how many women are proud of being weak. On a totally different note: Do any of the other women on the forum have problems with other women commenting on the amount of protein that they eat? Ug. I have had many conversations with friends about this subject, and all I have to say is: Please acknowledge that there are some people who do have genetic factors that will cause them to be overweight. Is that true for the majority of Americans? No(We’re talking 1 in a couple thousand). However, people who have these problems and the like should not have to listen (again) to how their excess weight is their own fault. Do you blame the cancer patient for losing weight during chemo? No. Don’t blame the people with true health issues. (Ok, this is usually the point where I get asked how I can say this, so I will continue with the monologue.) Two years ago I started experiencing extreme weight gain (i.e. 20 lbs in 4 weeks). Needless to say, I freaked out. I was doing light cario, lifting weights, eating only meat and raw vegetables, keeping a food journal, and eventually tracking calories. I went into the doctor and found out (months later) that my body had stopped producing estrogen and was storing fat to compensate. All in all, I gained 55 lbs in 6 months. I am still trying to get back to my normal weight (half way there!). I will never forget the cruel comments that I received from friends and acquaintances and I make an effort to never put anyone else in that position.

On a different note: Awesome post on women and weight lifting! As a college age female I am always suprised at how many women are proud of being weak.

On a totally different note: Do any of the other women on the forum have problems with other women commenting on the amount of protein that they eat?

]]> By: Patri Friedman http://www.marksdailyapple.com/control-gene-expression/#comment-415004 Patri Friedman Sun, 05 Jul 2009 20:43:49 +0000 http://www.marksdailyapple.com/control-gene-expression/#comment-415004 The standard way to measure nature vs. nurture tells us how much variation in outcome comes from variation in genes vs. variation in environment. This means that it isn't a fixed, objective number - it depends on how much variation in the environment there is. If everyone followed the same American diet and there was no Primal Blueprint, then heredity would be 100% - with no environmental variation, genes are all that is left. If the Primal Blueprint got really popular, so that many people had the standard American diet & exercise, but many people were Primal, that would *increase* environmental variation, and the genetic heredity number would go down! In other words, it isn't an absolute number, it just reflects how much influence nature has with the current variation in nurture. It doesn't tell you how much influence nurture can have. The standard way to measure nature vs. nurture tells us how much variation in outcome comes from variation in genes vs. variation in environment.

This means that it isn’t a fixed, objective number – it depends on how much variation in the environment there is. If everyone followed the same American diet and there was no Primal Blueprint, then heredity would be 100% – with no environmental variation, genes are all that is left. If the Primal Blueprint got really popular, so that many people had the standard American diet & exercise, but many people were Primal, that would *increase* environmental variation, and the genetic heredity number would go down!

In other words, it isn’t an absolute number, it just reflects how much influence nature has with the current variation in nurture. It doesn’t tell you how much influence nurture can have.

]]> By: Magnificent Muscle | Mark's Daily Apple http://www.marksdailyapple.com/control-gene-expression/#comment-408920 Magnificent Muscle | Mark's Daily Apple Fri, 26 Jun 2009 21:06:20 +0000 http://www.marksdailyapple.com/control-gene-expression/#comment-408920 [...] between muscle mass and organ reserve, and the impact of lifestyle on both disease risk and gene expression. How do you like that for [...] [...] between muscle mass and organ reserve, and the impact of lifestyle on both disease risk and gene expression. How do you like that for [...]

]]> By: Swifty http://www.marksdailyapple.com/control-gene-expression/#comment-284244 Swifty Mon, 09 Feb 2009 23:02:31 +0000 http://www.marksdailyapple.com/control-gene-expression/#comment-284244 Sorry I some how mispelt eat as It. So i mean Eat loads + no exersize = get fat Sorry I some how mispelt eat as It.

So i mean

Eat loads + no exersize = get fat

]]> By: Swifty http://www.marksdailyapple.com/control-gene-expression/#comment-284239 Swifty Mon, 09 Feb 2009 23:00:29 +0000 http://www.marksdailyapple.com/control-gene-expression/#comment-284239 I think there is one point that probably needs to be said. Being obees is genetic no doubt about it. It loads + no exersize = get fat It IS in are genes its just a shame the researches (sometimes) over look this small but very impotant formula! Now I want geneticist to come up with a cure! Then I can be a couch potatoe and eat McDonalds all the time. (and toffe popcorn) I think there is one point that probably needs to be said.

Being obees is genetic no doubt about it.

It loads + no exersize = get fat

It IS in are genes its just a shame the researches (sometimes) over look this small but very impotant formula!

Now I want geneticist to come up with a cure!

Then I can be a couch potatoe and eat McDonalds all the time. (and toffe popcorn)

]]> By: Mark’s Daily Apple » Blog Archive » Gene Expression: Location, Location, Location http://www.marksdailyapple.com/control-gene-expression/#comment-75100 Mark’s Daily Apple » Blog Archive » Gene Expression: Location, Location, Location Fri, 16 May 2008 15:32:17 +0000 http://www.marksdailyapple.com/control-gene-expression/#comment-75100 [...] Nature Tops Nurture? Scientists Wrong Again… [...] [...] Nature Tops Nurture? Scientists Wrong Again… [...]

]]> By: Medij.com blog » Childhood Obesity: Nature or Nurture? http://www.marksdailyapple.com/control-gene-expression/#comment-31109 Medij.com blog » Childhood Obesity: Nature or Nurture? Mon, 25 Feb 2008 22:20:56 +0000 http://www.marksdailyapple.com/control-gene-expression/#comment-31109 [...] Mark’s Daily Apple, for example, where the Impressively Healthy hang out, they noted that there is still a big [...] [...] Mark’s Daily Apple, for example, where the Impressively Healthy hang out, they noted that there is still a big [...]

]]> By: Mark’s Daily Apple » Blog Archive » Good Night and Good Health http://www.marksdailyapple.com/control-gene-expression/#comment-28896 Mark’s Daily Apple » Blog Archive » Good Night and Good Health Wed, 13 Feb 2008 16:01:12 +0000 http://www.marksdailyapple.com/control-gene-expression/#comment-28896 [...] comes to the health of our seedlings (or any of us, for that matter)… Last week Mark offered commentary on an analysis of twins and childhood obesity published in the American Journal of Clinical [...] [...] comes to the health of our seedlings (or any of us, for that matter)… Last week Mark offered commentary on an analysis of twins and childhood obesity published in the American Journal of Clinical [...]

]]> By: markus http://www.marksdailyapple.com/control-gene-expression/#comment-28402 markus Mon, 11 Feb 2008 16:14:34 +0000 http://www.marksdailyapple.com/control-gene-expression/#comment-28402 one important thing that gets lost in the genes debate is the fact that genetic variability is in fact a PRODUCT of evolutionary environmental interaction. Genetic variability, not genetic defects (except in rare mutations), is how we should be conceiving it. This obsession with genetic influence on disease is a product of the current paradigm which is led by pharmaceutical companies angling for a patented "treatment". Conceived as genetic evolutionary heritage, genes can be seen as modifying factors in pathenogenesis. In that they influence the DEGREE to which we suffer from, in this case, a bad diet. In fact, all the data from the turn of the century, when colonial doctors consistently reported that traditional societies were free from the "diseases of civilization" - and were consistently found to deteriorate when influenced by western foodways - showed that it is indeed nature that is the key influence. the reason why the establishment and researchers concentrate on drug treatment is both because that's where the money is and because the failed low fat experiment has caused universal cynicism among nutritionists and the public. It doesn't prompt them to question their theory's failure, so they now seek desperately the drug route. It's a recipe for disaster - note the recent ACCORD "study". http://feeds.feedburner.com/~r/drmikenutritionblog/~3/232300613/ look how far we have come down the path of foolishness.. at least there are a few good voices in this medical wilderness. all the best Mark (and everyone else posting) Markus one important thing that gets lost in the genes debate is the fact that genetic variability is in fact a PRODUCT of evolutionary environmental interaction. Genetic variability, not genetic defects (except in rare mutations), is how we should be conceiving it. This obsession with genetic influence on disease is a product of the current paradigm which is led by pharmaceutical companies angling for a patented “treatment”. Conceived as genetic evolutionary heritage, genes can be seen as modifying factors in pathenogenesis. In that they influence the DEGREE to which we suffer from, in this case, a bad diet.

In fact, all the data from the turn of the century, when colonial doctors consistently reported that traditional societies were free from the “diseases of civilization” – and were consistently found to deteriorate when influenced by western foodways – showed that it is indeed nature that is the key influence.

the reason why the establishment and researchers concentrate on drug treatment is both because that’s where the money is and because the failed low fat experiment has caused universal cynicism among nutritionists and the public. It doesn’t prompt them to question their theory’s failure, so they now seek desperately the drug route. It’s a recipe for disaster – note the recent ACCORD “study”. http://feeds.feedburner.com/~r/drmikenutritionblog/~3/232300613/

look how far we have come down the path of foolishness..

at least there are a few good voices in this medical wilderness.

all the best Mark (and everyone else posting)

Markus

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