I received tons of emails from last week’s Gene Expression: Location, Location, Location post. Thanks to everybody for their feedback and questions. In the comment section of last week’s post, Ed was interested in other concrete examples of gene expression (the ability of a gene to produce a biologically active protein). In personal emails, others asked for more explanation of the difference between genes and gene expression. Still others wanted to hear more about the interaction between their gene expression and lifestyle choices. Given the range of reader questions this week, I thought I’d reframe this week’s Dear Mark to include more of an overview of this recurring MDA theme. There’s a lot to be said on the subject, and I promise this post won’t be the last word on it. Nonetheless, there’s no time like the present to give a proper introduction and dive right in.
Let me just say that gene expression is one of my favorite areas of interest, and it’s truly at the heart of the Primal Blueprint. In fact, it’s the real beauty of it as well. It confirms that the day-to-day choices we make have incredible impact. And we can influence gene expression to a far greater degree than anyone ever thought possible.
Geneticists at North Carolina State University have revealed an interesting lesson in gene expression: where you live can have significant impact on how your genes are expressed.
The scientists focused on a sample of 46 Moroccan Amazighs, a relatively homogenous group genetically-speaking. The subjects included desert nomads, mountain agrarians and coastal urban residents. The researchers analyzed the white blood cells of the group “to study the impact of the transition from traditional to urbanized lifestyles on the human immune system.” The results surprised even the scientists themselves: gene expression in the group varied by up to one-third based on geographic location and corresponding lifestyle.
They just don’t get it. Maybe they never will.
Reader Karen was outraged enough to send us a link to a news story on MSNBC that states “Nature tops nurture for heavy kids, study says. Research on twins finds that weight is 77 percent attributable to genes.” Thanks, Karen.
Read the abstract here.
Cool news for your Monday – Researchers from Duke University have discovered a way to examine the entire genome and find the “unpackaged” centers that direct gene expression:
A new resource that identifies regions of the human genome that regulate gene expression may help scientists learn about and develop treatments for a number of human diseases, according to researchers at Duke’s Institute for Genome Sciences & Policy (IGSP). … “Scientists have used similar methods to look at tiny portions of the genome in the past, but ours is the first technology to really allow researchers to look at the whole genome, so we can see all of the areas where gene regulation occurs,” said Terrence Furey, Ph.D., a researcher in the IGSP and co-senior investigator on this study. “Identifying these sites may help us understand the biological basis for gene regulation expression patterns in different cell types. We’ll also compare patterns within and across species, in response to external stimuli and in diseased tissues.”
via Science Daily
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