Marks Daily Apple
Serving up health and fitness insights (daily, of course) with a side of irreverence.

Archive for the ‘ Gene Expression ’ Category

15 Aug

You Are What Your Mother and Father (and Grandmothers and Grandfathers) Ate

On September 11, 2001, passenger jets struck the Twin Towers, leveling them, killing thousands of New Yorkers, and traumatizing tens of thousands more. Among those directly affected, but not killed, by the attack were 1700 pregnant women. Some of those women developed post traumatic stress disorder, some did not. When the PTSD-positive group had their […]

18 Dec

Should You Get Your Genome Sequenced?

Earlier this year, I explored the “evolution” of human dietary requirements in the last 10,000 years by examining some of the SNPs – single nucleotide polymorphisms, or variations in genetic sequences – that relate to diet and nutrition. I concluded that while certain genetic changes to the way we process certain foods have arisen in […]

25 Oct

What About Type 1 Diabetes?

You hear a lot about type 2 diabetes on this and other sites in the community. It’s easy to see why: type 2 diabetes is the “lifestyle” diabetes, the preventable one, the one that “doesn’t have to happen” and that you can “fix if you just dial in the food.” All true, for the most […]

26 Jul

Are We Pre-Programmed to Be Happy?

I think we can all agree that a basic goal in life is the attainment of happiness, that mind state characterized by positive and pleasant thoughts and emotions. But how do we become happy? By definition, happiness requires some type of pleasure to be present. We need good feelings and good physical sensations. Furthermore, the […]

3 Apr

Why Fast? Part Four – Brain Health

Pretty much every feature of the human body can be found, in some form or another, on other species. Opposable thumbs? Great for building and using tools, but apes have them, too. Even the giant panda has an opposable sesamoid bone that works like a thumb. Bipedalism? Helped us avoid direct mid-afternoon sun and carry […]

29 Mar

Maybe There is Such a Thing as Too Much Information

A couple weeks back, the LA Times published a piece on a geneticist’s experience with “personalized medicine.” Based on careful and constant monitoring of his sequenced DNA and around 40,000 health markers – or “omics” – over 14 months by a team of his colleagues, Stanford geneticist Michael Snyder observed in painstaking detail exactly what […]

27 Mar

Why Fast? Part Three – Longevity

A time-honored and research-tested way to extend an animal’s lifespan is to restrict its caloric intake. Studies repeatedly confirm that if, say, a lab mouse normally gets two full bowls of lab chow a day, limiting that mouse to one and a half bowls of lab chow a day will make that mouse live longer […]

4 Jan

How Much Have Human Dietary Requirements Evolved in the Last 10,000 Years?

A hallmark of the Primal Blueprint is that our genetics were shaped by our ancestral environment. That the foods to which we had access, the amount of sun and stress and sleep to which our bodies became accustomed, the movement patterns in which we engaged represented environmental factors that exerted selective pressure on our genetic […]

1 Nov

Managing Your Mitochondria: Exercise

A couple weeks ago, I wrote about how becoming an efficient fat-burner helps mitochondrial function, and last week I went over some of the nutrients and supplements most important for your mitochondria. All good and all useful, but today I’m going to talk about another route: exercise. It makes intuitive sense that mitochondria are profoundly […]

26 Oct

What If I Don’t Want to Lose Weight?

I receive a lot of emails from folks worried about losing too much weight on the Primal Blueprint, underweight readers who need to gain weight, or the formerly overweight who have reached their target weight and wish to stay put. No, they don’t outnumber the questions from overweight readers, but that’s to be expected given […]

28 Feb

Did a Wrinkle in Human Evolution Predispose Us to Diabetes?

A new mice-with-an-engineered-human-genetic-deficiency study is out that promises to shed light on why humans are so darn diabetic and obese – and the cause is an evolutionary “mistake.” A deficiency that apparently slipped through the cracks without somehow leading to our species’ demise. You see, we’re missing a genetic component shared by pretty much all […]

16 Feb

The Myriad Benefits of Intermittent Fasting

Calorie restriction is all the rage in anti-aging circles. A few mice and worm studies seem to show that drastic reductions in food intake over a long period of time have the effect of prolonging life – although I’m not sure I’d call it living. For one, these animals are actually restricted. There’s no ad […]

17 Jan

Monday Musings: Intergenerational Diabetes, New and Improved Pasteurization, Sitting is Still Bad, and Really Old Wine

Diabetes is that rare brand of nasty disease that fails to strike real, visceral fear. It doesn’t carry the weight of a cancer or an AIDS or a heart disease. It’s something you get, like a gut, a long list of prescriptions, and a walker, as you grow older. People just live with it – […]

12 Jan

Why Can Some People Eat Anything They Want and Never Gain a Pound?

The following are both actual and paraphrased versions of questions I regularly get from readers: If grains are so bad how can you explain the leanness and good health of Clarence Bass? How is it that this guy can eat 30 bananas a day and not gain weight, or this guy can eat nothing but […]

16 Dec

Why You Should Practice Deep Breathing (and How to Do It)

Stressed, anyone? Whether it’s the holidays, the weather, or just the same old tensions, you know that stress takes its toll on your well-being. Sure, you’d love to motivate yourself to take up a meditation practice, yoga class or some other endeavor that promises an effective retreat from the weight of daily pressures. (A vacation […]

8 Nov

Monday Musings: Poop Transplants, Sleep Deprivation and Going Nuts

And now for another round of Monday Musings… Let’s Talk Sh** Poop is the new probiotic. Doctors have been using fecal transplants as a “last resort,” mostly to treat the rising scourge of Clostridium difficile, a gut bug that affects about 250,000 Americans every year and proves extremely resistant to antibiotics. Shooting a fecal extract from […]

26 Aug

Learning from Moose

Life adapts when necessitated by changing conditions that impact survival. These are evolutionary pressures, with nutrition being probably the strongest. Flora bend toward the sun and plunge rooty tendrils deep into soil in search of moisture and minerals, while mobile organisms walk, run, fly, crawl, scrounge, or swim for food. Herbivores prefer to go where […]

24 May

Dear Mark: Latest in Gene Expression Research

One of my favorite topics, as many of you know, is epigenetics. It’s the burgeoning area of science that has blown apart the traditional nature-nurture dichotomy by examining the lifestyle-induced activation or dampening of genes. Epigenetics is increasingly filling in the gaps for understanding and monitoring degenerative disease risk. If you’re relatively new to MDA, […]

1 Mar

Dear Mark: Embodied Cognition

The following reader email brought to mind a NY Times article I read a few weeks ago. The article discusses a fairly new field of research that is uncovering the surprisingly fundamental and intricate ways our bodies influence our thinking and vice-versa. We’ve discussed the mind-body connection in the past, but embodied cognition puts the […]

20 Feb

What I Mean by “Reprogram Your Genes”

From time to time I’ll get a comment from a skeptical reader that says something like, “I don’t think it’s possible to reprogram your genes through diet/lifestyle. Of course our genes are set at birth and our DNA, or program, is copied into every cell of our bodies. You cannot modify or reprogram your genetic […]

© 2014 Mark's Daily Apple