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Are Antioxidant Supplements Effective?
Posted By Mark Sisson On March 18, 2014 @ 8:00 am In Supplements | 37 Comments
If you pay attention to science journalism, you’ve probably heard tell that antioxidant supplements have mostly negative effects on health markers, ranging from impaired training adaptations in response to exercise, extreme hypoglycemia, and even cancer. At their best, these reports say, antioxidants are merely useless and totally ineffective.
So, is this true? Are antioxidants harmful? Are they effective?
Let’s examine some of the specific claims made about antioxidant supplements.
Sometimes they reduce them, sometimes they enhance them, and sometime they have a neutral effect. It depends on several factors.
It depends on your baseline oxidative stress status. Giving antioxidant supplements to heart disease patients on an exercise regimen did not reduce the benefits of exercise . CHD patients typically have elevated oxidative stress markers .
It depends on your age. In elderly exercisers, taking a green tea and vitamin E supplement actually enhanced the effects of exercise . They improved body composition, glucose tolerance, and oxidative stress load to a greater degree upon antioxidant supplementation, probably because older people are more susceptible to oxidative stress induced by exercise .
It depends on your body composition. One of the more recent  “antioxidants cancel out exercise” studies actually suggests that obese people enjoy improved body fat loss when supplementing and exercising. And even though the healthy trainees who supplemented showed biomarkers that normally indicate impaired training adaptations, their V02 max and running performance compared favorably to those who did not supplement.
It depends on the nature of the exercise. The more antioxidants you take, the higher your tolerance for greater intensities. You’ll likely “need” more intensity. That may be why giving antioxidants to people engaged in high intensity interval training does not reduce the benefits .
Pick an antioxidant, any antioxidant, and you’ll find people online complaining about it causing low blood sugar. How can this be if antioxidants are “good for you”?
Many (and perhaps most) antioxidants are insulin-sensitizing agents. They increase the effects of insulin, a primary one of which is the removal of glucose  from the blood, so you need less insulin to remove the same amount of glucose. Or put another way, the same amount of insulin  removes even more glucose. If you’re lean, if you’re perfectly insulin sensitive, if you’re walking around with optimal blood glucose levels, consuming an insulin-sensitizing agent may be too much of a good thing. It may make you hypoglycemic.
What if you’re not healthy? If you’re a type 2 diabetic, if you’re completely sedentary, if you’re obese and insulin resistant, if you’re hyperglycemic, more insulin sensitivity will improve your health. Context matters. Always.
That’s why the same alpha lipoic acid that might cause hypoglycemia has also been shown to prevent the descent  from glucose intolerance into full-blown type 2 diabetes and increase insulin sensitivity in type 2 diabetics . Or why the curcumin that may cause low blood sugar in healthy people can reduce the incidence of type 2 diabetes  diagnoses in an at-risk cohort. In other words, it helps the people who need the help.
A headline like “Antioxidants Could Increase Cancer Rates ” implies that supplements are increasing the incidence of cancer in the population. Looking at the study  it draws upon, you realize that vitamin E and NAC  “only” accelerated tumor growth in mice with pre-existing tumors rather than spurred the formation of new ones. That’s understandable, as cancer patients undergoing radiation or chemo therapy are usually told not to discontinue any antioxidant supplementation.
Meanwhile, other evidence shows that NAC is chemopreventive  (inhibits cancer from starting), especially when combined with other antioxidants like green tea extract . It’s also safe to assume that the vitamin E used in this study was alpha tocopherol, whereas broad-spectrum vitamin E that includes tocotrienols tends to slow the progression  of cancer.
Certain antioxidants may very well spur progression of (some) existing cancers, but that’s not the same as increasing the incidence of cancer.
They’re studying the wrong populations. Healthy people are not the same as unhealthy people. They respond differently to medications, foods, exercise regimens, and yes, antioxidants.
In healthy men, grape polyphenol extracts don’t improve vascular function . In men with metabolic syndrome, grape polyphenol extracts lower blood pressure and increase flow-mediated dilation . Similar differences have been observed with resveratrol , too. And despite that, antioxidants sometimes do work, even in generally healthy populations; a complex of quercetin, curcumin, catechins, and selenium improved  cardiovascular disease markers after two months.
Notice a trend? Antioxidant supplements are generally beneficial for unhealthy people with high baseline levels of oxidative stress  and systemic inflammation , while they can be unhelpful for people who are already healthy with low levels of oxidative stress and systemic inflammation. Unfortunately, most people fall into the former category.
Take me, for example.
Back when I first got started on the Primal road to better health, I was a mess. Overtraining, chronic stress, inflammation – the years of abusing my body in the pursuit of elite endurance performance had not been kind. I designed my antioxidant supplement (Damage Control Master Formula ) to counter all that oxidative stress I was subjecting myself to. And, in concert with smarter (less) training, a better (more Primal) way of eating, and other lifestyle interventions (stress , sleep , play , etc.), it seemed to help. It was actually a very selfish endeavor – I just wanted to get healthier, faster, so I put together a spectrum of safe, natural compounds and extracts that satisfied my criteria:
Nowadays, I’ve got my health dialed in. I eat right, move correctly, sleep well, and kinda-sorta handle stress adequately. I don’t need to take an antioxidant supplement on a daily basis, so I take it intermittently. One pill after breakfast one day, three the next day, and none for half a week. Then I’ll take it every other day at varying dosages, then back off for another half week. That’s just an example, not a prescription. I jump around, basically. What’s funny is that because I’m fairly healthy, taking Master Formula every day could conceivably offer diminishing, or even negative returns. The same negative effects you see bandied about. Taking it the way I do now has a hormetic effect , the phenomenon whereby a moderate stressor upregulates your own antioxidant mechanisms to make you healthier and more robust.
The bottom line of all this? Figure out where you stand.
A severely obese  person might benefit from more regular usage. An extremely active, high-performing, daily-training athlete would probably benefit from semi-regular usage. A heart disease  patient might look into supplementation. And I imagine a person working 15 hour days at a high-stress job could probably benefit from antioxidant supplementation. These are people who are inflamed, who are coming into the game with a hefty load of oxidative stress. They can probably use the extra help.
If you’re eating well , exercising intelligently , getting as much sleep  as you need, and not suffering from any obvious maladies, you don’t “need” to take an antioxidant supplement. You might benefit from the occasional hormetic dose – as I believe I do – especially if you don’t eat enough phytonutrient-rich plant food , but you’ll be okay without it.
See how it works? Rather confusingly. There are no easy answers, only choices – often hard ones – we must make based on our personal situations.
Let’s hear from you guys. Do you take any antioxidants? Why or why not?
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 did not reduce the benefits of exercise: http://www.ncbi.nlm.nih.gov/pubmed/21427602
 elevated oxidative stress markers: http://www.ncbi.nlm.nih.gov/pubmed/19656058
 enhanced the effects of exercise: http://www.ncbi.nlm.nih.gov/pubmed/24015697
 more susceptible to oxidative stress induced by exercise: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0090420
 more recent: http://jp.physoc.org/content/early/2014/01/31/jphysiol.2013.267419.abstract
 does not reduce the benefits: http://www.ncbi.nlm.nih.gov/pubmed/21487150
 glucose: http://www.marksdailyapple.com/how-much-glucose-does-your-brain-really-need/
 insulin: http://www.marksdailyapple.com/diabetes/
 prevent the descent: http://www.ncbi.nlm.nih.gov/pubmed/24361606
 increase insulin sensitivity in type 2 diabetics: http://www.ncbi.nlm.nih.gov/pubmed/17178700
 reduce the incidence of type 2 diabetes: http://www.ncbi.nlm.nih.gov/pubmed/22773702
 Antioxidants Could Increase Cancer Rates: http://news.sciencemag.org/biology/2014/01/antioxidants-could-increase-cancer-rates
 study: http://stm.sciencemag.org/content/6/221/221ra15.abstract
 NAC: http://www.marksdailyapple.com/glutathione-cartilage-regeneration/
 NAC is chemopreventive: http://www.ncbi.nlm.nih.gov/pubmed/23104176?dopt=AbstractPlus
 green tea extract: http://www.ncbi.nlm.nih.gov/pubmed/18206665?dopt=AbstractPlus
 slow the progression: http://www.ncbi.nlm.nih.gov/pubmed/23963802
 grape polyphenol extracts don’t improve vascular function: http://www.ncbi.nlm.nih.gov/pubmed/20702747
 lower blood pressure and increase flow-mediated dilation: http://www.ncbi.nlm.nih.gov/pubmed/22810991
 resveratrol: http://www.impactaging.com/papers/v5/n7/full/100579.html
 improved: http://www.ncbi.nlm.nih.gov/pubmed/23331204
 oxidative stress: http://www.marksdailyapple.com/dear-mark-sleep-and-oxidative-stress/
 systemic inflammation: http://www.marksdailyapple.com/inflammation/
 Damage Control Master Formula: http://www.primalblueprint.com/product/Damage_Control_Master_Formula/Supplements
 stress: http://www.marksdailyapple.com/rethinking-stress-it-could-save-your-life/
 sleep: http://www.marksdailyapple.com/how-to-get-fitter-faster-and-stronger-with-quality-sleep/
 play: http://www.marksdailyapple.com/15-concrete-ways-to-play/
 hormetic effect: http://www.marksdailyapple.com/hormesis-how-certain-kinds-of-stress-can-actually-be-good-for-you/
 obese: http://www.marksdailyapple.com/is-obesity-a-disease/
 heart disease: http://www.marksdailyapple.com/how-might-inflammation-cause-heart-disease/
 eating well: http://www.marksdailyapple.com/definitive-guide-to-the-primal-eating-plan/
 exercising intelligently: http://www.marksdailyapple.com/the-best-exercise-there-is-hands-down/
 getting as much sleep: http://www.marksdailyapple.com/how-to-manufacture-the-best-night-of-sleep-in-your-life/
 phytonutrient-rich plant food: http://www.marksdailyapple.com/do-you-really-need-to-eat-vegetables-to-be-healthy/
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